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Rockland
Zic-1 Polyclonal Antibody
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Product Details
200-401-159
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
The whole rabbit serum used to produce this IgG fraction antibody was prepared by repeated immunizations with an 18 aa synthetic peptide from a region near the N-Terminus of mouse Zic-1. This domain is completely conserved in human ZIC-1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Ion-exchange chromatography
Storage buffer
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This is an IgG preparation of whole rabbit antiserum purified by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. This antibody is directed against Zic-1 from mouse. In general, this antibody also detects human Zic-1. Cross-reactivity with other species is likely but has not been determined.
Target Information
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: odd-paired homolog; Zic family member 1 (odd-paired homolog, Drosophila); Zinc finger protein 201; Zinc finger protein of the cerebellum 1; Zinc finger protein ZIC 1
Gene Aliases: CRS6; ZIC; ZIC1; ZNF201
UniProt ID: (Human) Q15915, (Mouse) P46684
Entrez Gene ID: (Human) 7545, (Mouse) 22771
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
metal ion binding
nucleic acid binding
DNA binding
protein binding
C2H2 zinc finger transcription factor
transcription from RNA polymerase II promoter
pattern specification process
brain development
adult walking behavior
regulation of smoothened signaling pathway
spinal cord development
cell differentiation
positive regulation of protein import into nucleus
inner ear morphogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
skeletal system development
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
nervous system development
central nervous system development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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