PA1-048 detects alpha-2A adrenergic receptor (A2AAR) from human, rat and mouse tissues.
PA1-048 has been successfully used in Western blot and immunohistochemistry procedures. By Western blot, this antibody detects an ~45 kDa protein representing A2AAR from mouse kidney membrane preparations.
The PA1-048 immunogen is a synthetic peptide corressponding to residues R(218) I Y Q I A K R R T R V P P S R R G(235) of the 3rd intracellular loop of human A2AAR. This sequence is completely conserved between human, mouse, rat, and porcine A2AAR.
Alpha-2-adrenergic receptors (ADRA2A) are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. ADRA2A mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G protein. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: adrenergic receptor, alpha 2a; adrenergic, alpha-2A-, receptor; Alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type; Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; alpha-2AAR; alpha-2AAR subtype C10; Alpha-2D adrenergic receptor; alpha2A-adrenergic receptor; CA2-47; OTTHUMP00000058849; subtype alpha2-C10
Gene Aliases: Adra-2; Adra-2a; ADRA2; ADRA2A; ADRA2R; ADRAR; alpha(2A)AR; alpha2-C10; alpha2A; alpha2A-AR; ALPHA2AAR; AW122659; CA2-47; RATRG20; RG20; ZNF32