Invitrogen

alpha-2a Adrenergic Receptor Polyclonal Antibody

8 Published Figures
15 References
View all (11) alpha-2a Adrenergic Receptor antibodies

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alpha-2a Adrenergic Receptor Polyclonal Antibody

Product Details

PA1-048

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
View 6 publications 6 publications

Immunohistochemistry (IHC)

-
View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000
-

Immunohistochemistry (Frozen) (IHC (F))

-
View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corressponding to residues R(218) I Y Q I A K R R T R V P P S R R G(235) of the 3rd intracellular loop of human A2AAR.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.6 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2225243

Product Specific Information

PA1-048 detects alpha-2A adrenergic receptor (A2AAR) from human, rat and mouse tissues.

PA1-048 has been successfully used in Western blot and immunohistochemistry procedures. By Western blot, this antibody detects an ~45 kDa protein representing A2AAR from mouse kidney membrane preparations.

The PA1-048 immunogen is a synthetic peptide corressponding to residues R(218) I Y Q I A K R R T R V P P S R R G(235) of the 3rd intracellular loop of human A2AAR. This sequence is completely conserved between human, mouse, rat, and porcine A2AAR.

Target Information

Alpha-2-adrenergic receptors (ADRA2A) are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. ADRA2A mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G protein. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: adrenergic receptor, alpha 2a; adrenergic, alpha-2A-, receptor; Alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type; Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; alpha-2AAR; alpha-2AAR subtype C10; Alpha-2D adrenergic receptor; alpha2A-adrenergic receptor; CA2-47; OTTHUMP00000058849; subtype alpha2-C10

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Gene Aliases: Adra-2; Adra-2a; ADRA2; ADRA2A; ADRA2R; ADRAR; alpha(2A)AR; alpha2-C10; alpha2A; alpha2A-AR; ALPHA2AAR; AW122659; CA2-47; RATRG20; RG20; ZNF32

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UniProt ID: (Human) P08913, (Mouse) Q01338, (Rat) P22909

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Entrez Gene ID: (Human) 150, (Mouse) 11551, (Rat) 25083

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Function(s)
alpha2-adrenergic receptor activity protein binding protein kinase binding alpha-1B adrenergic receptor binding alpha-2C adrenergic receptor binding thioesterase binding heterotrimeric G-protein binding protein homodimerization activity protein heterodimerization activity epinephrine binding norepinephrine binding adrenergic receptor activity G-protein coupled receptor
Process(es)
positive regulation of cytokine production acute inflammatory response DNA replication movement of cell or subcellular component signal transduction G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity Ras protein signal transduction Rho protein signal transduction female pregnancy positive regulation of cell proliferation negative regulation of norepinephrine secretion regulation of vasoconstriction actin cytoskeleton organization platelet activation positive regulation of cell migration negative regulation of cAMP biosynthetic process activation of protein kinase activity activation of protein kinase B activity negative regulation of epinephrine secretion cellular response to hormone stimulus epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway glucose homeostasis positive regulation of potassium ion transport positive regulation of MAP kinase activity positive regulation of epidermal growth factor-activated receptor activity positive regulation of vasodilation negative regulation of calcium ion-dependent exocytosis negative regulation of insulin secretion regulation of insulin secretion intestinal absorption thermoception negative regulation of lipid catabolic process positive regulation of membrane protein ectodomain proteolysis negative regulation of calcium ion transport negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of uterine smooth muscle contraction negative regulation of adrenergic receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-inhibiting adrenergic receptor signaling pathway phospholipase C-activating adrenergic receptor signaling pathway activation of MAPK activity by adrenergic receptor signaling pathway positive regulation of wound healing negative regulation of calcium ion transmembrane transporter activity cell-cell signaling fear response adrenergic receptor signaling pathway regulation of smooth muscle contraction
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