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Invitrogen

alpha-2a Adrenergic Receptor Polyclonal Antibody

8 Published Figures
15 References
View all (11) alpha-2a Adrenergic Receptor antibodies

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alpha-2a Adrenergic Receptor Polyclonal Antibody

Product Details

PA1-048

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
View 6 publications 6 publications

Immunohistochemistry (IHC)

-
View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000
-

Immunohistochemistry (Frozen) (IHC (F))

-
View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corressponding to residues R(218) I Y Q I A K R R T R V P P S R R G(235) of the 3rd intracellular loop of human A2AAR.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.6 mg/mL

Amount

60 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2225243

Product Specific Information

PA1-048 detects alpha-2A adrenergic receptor (A2AAR) from human, rat and mouse tissues.

PA1-048 has been successfully used in Western blot and immunohistochemistry procedures. By Western blot, this antibody detects an ~45 kDa protein representing A2AAR from mouse kidney membrane preparations.

The PA1-048 immunogen is a synthetic peptide corressponding to residues R(218) I Y Q I A K R R T R V P P S R R G(235) of the 3rd intracellular loop of human A2AAR. This sequence is completely conserved between human, mouse, rat, and porcine A2AAR.

Target Information

Alpha-2-adrenergic receptors (ADRA2A) are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. ADRA2A mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G protein. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: adrenergic receptor, alpha 2a; adrenergic, alpha-2A-, receptor; Alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type; Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; alpha-2AAR; alpha-2AAR subtype C10; Alpha-2D adrenergic receptor; alpha2A-adrenergic receptor; CA2-47; OTTHUMP00000058849; subtype alpha2-C10

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Gene Aliases: Adra-2; Adra-2a; ADRA2; ADRA2A; ADRA2R; ADRAR; alpha(2A)AR; alpha2-C10; alpha2A; alpha2A-AR; ALPHA2AAR; AW122659; CA2-47; FPLD8; RATRG20; RG20; ZNF32

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UniProt ID: (Human) P08913, (Mouse) Q01338, (Rat) P22909

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Entrez Gene ID: (Human) 150, (Mouse) 11551, (Rat) 25083

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Function(s)
G-protein coupled receptor activity adrenergic receptor activity alpha2-adrenergic receptor activity guanyl-nucleotide exchange factor activity protein binding protein kinase binding alpha-1B adrenergic receptor binding alpha-2C adrenergic receptor binding thioesterase binding heterotrimeric G-protein binding protein homodimerization activity protein heterodimerization activity epinephrine binding norepinephrine binding G-protein coupled receptor
Process(es)
positive regulation of cytokine production DNA replication regulation of smooth muscle contraction signal transduction epidermal growth factor receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Ras protein signal transduction Rho protein signal transduction female pregnancy positive regulation of cell proliferation negative regulation of norepinephrine secretion regulation of vasoconstriction actin cytoskeleton organization platelet activation positive regulation of cell migration negative regulation of epinephrine secretion cellular response to hormone stimulus vasodilation glucose homeostasis fear response positive regulation of potassium ion transport response to morphine positive regulation of MAPK cascade positive regulation of epidermal growth factor receptor signaling pathway negative regulation of calcium ion-dependent exocytosis negative regulation of insulin secretion intestinal absorption thermoception negative regulation of lipid catabolic process positive regulation of membrane protein ectodomain proteolysis positive regulation of protein kinase B signaling negative regulation of calcium ion transport negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of uterine smooth muscle contraction adrenergic receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-inhibiting adrenergic receptor signaling pathway phospholipase C-activating adrenergic receptor signaling pathway positive regulation of wound healing response to alcohol presynaptic modulation of chemical synaptic transmission acute inflammatory response negative regulation of adenylate cyclase activity cell-cell signaling negative regulation of cAMP biosynthetic process activation of protein kinase activity activation of protein kinase B activity epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway positive regulation of MAP kinase activity positive regulation of epidermal growth factor-activated receptor activity positive regulation of vasodilation activation of MAPK activity by adrenergic receptor signaling pathway
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