PA5-27166 targets alpha 2c Adrenergic Receptor in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-27166 immunogen is synthetic peptide corresponding to a region within amino acids 318 and 409 of Human alpha 2c Adrenergic Receptor.
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Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
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Protein Aliases: ADRA2L2; ADRA2RL2; ADRARL2; adrenergic, alpha-2C-, receptor; Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenergic receptor; Alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; alpha-2C-adrenergic receptor; alpha-2CAR; alpha2-AR-C4; ALPHA2CAR
Gene Aliases: ADRA2C; ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR
UniProt ID: (Human) P18825
Entrez Gene ID: (Human) 152