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alpha-2c Adrenergic Receptor Polyclonal Antibody
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FIGURE: 1 / 5
alpha-2c Adrenergic Receptor Antibody (PA5-33332) in IHC (P)
Immunohistochemistry analysis of alpha-2c Adrenergic Receptor in human Brain, Glioblastoma. Samples were incubated with alpha-2c Adrenergic Receptor polyclonal antibody (Product # PA5-33332). Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-33332
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 18 amino acid peptide from 2nd extracellular domain of human ADRA2C.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%) Mouse, Rat, Panda, Bovine, Dog, Guinea pig (94%) Hamster (89%).
Target Information
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adra 2c; adrenergic, alpha-2C-, receptor; Alpha 2CAR; Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenergic receptor; Alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; Alpha-2C-AR; alpha-2CAR; alpha2 AR C4; alpha2 C4; alpha2-AR-C4; kidney alpha-2-adrenergic receptor
Gene Aliases: ADRA2C; ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR
UniProt ID: (Human) P18825
Entrez Gene ID: (Human) 152
regulation of smooth muscle contraction
signal transduction
epidermal growth factor receptor signaling pathway
G-protein coupled receptor signaling pathway
cell-cell signaling
negative regulation of norepinephrine secretion
regulation of vasoconstriction
platelet activation
negative regulation of epinephrine secretion
positive regulation of MAPK cascade
positive regulation of neuron differentiation
negative regulation of insulin secretion
positive regulation of protein kinase B signaling
adrenergic receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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