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Invitrogen
DEFA1 Polyclonal Antibody
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Product Details
PA5-103122
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DEFA1; DEFA1B(Accession P59665), corresponding to amino acid residues I40-W90.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Defensin alpha1.
Target Information
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-defensin 1; Cryptdin-1; defensin 1; defensin related cryptdin peptide 1; Defensin, alpha 1; defensin, alpha 1, myeloid-related sequence; defensin, alpha 2; defensin-1; Defensin-related cryptdin peptide; HNP-1; HP-1; myeloid-related sequence; Neutrophil defensin 1; neutrophil peptide 1 precursor; unnamed protein product
Gene Aliases: DEF1; DEFA1; DEFA1B; DEFA2; Defcr; Defcr1; HNP-1; HP-1; HP1; MRS
UniProt ID: (Human) P59665, (Mouse) P11477
Entrez Gene ID: (Human) 1667, (Mouse) 13216
innate immune response in mucosa
chemotaxis
defense response
immune response
T cell chemotaxis
antibacterial humoral response
intracellular estrogen receptor signaling pathway
killing of cells of other organism
defense response to bacterium
defense response to protozoan
innate immune response
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
defense response to fungus
defense response to virus
membrane disruption in other organism
killing by host of symbiont cells
antimicrobial humoral immune response mediated by antimicrobial peptide
response to drug
cellular response to lipopolysaccharide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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