Immunogen sequence: MAEARSQPSA GPQLNALPDH SPLLQPGLAA LRRRAREAGV PLAPLPLTDS FLLRFLRARD FDLDLAWRLL KNYYKWRAEC PEISADLHPR SIIGLLKAGY HGVLRSRDPT; Positive Samples: Mouse liver, Mouse kidney, Rat liver; Cellular Location: Cytoplasm
This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa.
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Protein Aliases: alpha TTP; Alpha-tocopherol transfer protein; Alpha-TTP; Tocopherol transfer protein alpha
Gene Aliases: alpha-TTP; Tpp1; TTP; Ttpa