Hamburger Menu Button
Thermo Fisher Scientific Logo
登入
還沒有帳戶嗎 ? 立即註冊
  • 產品
    • Antibodies
    • Oligos, Primers, Probes and Genes
    • TaqMan Real-Time PCR Assays
    • Cell Culture Media
    • Chemicals
    • Western Blot Products
    • Chromatography Columns and Cartridges
    • Lab Equipment
    • Lab Plasticware and Supplies
    • Microplates
    • Greener Products
    • 查看所有產品類別
  • 應用
    • 生物製程
    • 細胞培養和轉染
    • 食品和飲料
    • 實驗室解決方案
    • 製藥和生物製藥
    • 即時定量PCR
    • 半導體分析
    • 臨床和診斷
    • 數位解決方案
    • 分子光譜、同位素與元素分析
    • 查看所有應用與技術
  • 服務
    • 360° CDMO 和 CRO 服務
    • CDMO 服务
    • 临床试验 CRO 服务
    • 客製化服務
    • 企業服務
    • 金融與租賃服務
    • 儀器服務
    • 實驗室資訊學
    • 授權與商業供應
    • 培訓服務
    • 查看所有服務
  • 支援
    • 線上訂購協助
    • 數位解決方案
    • 產品支持
    • 技術相關資訊
    • 培訓與教育
    • 查看所有協助與支援
  • 熱門商品
    • TaqMan Real-Time PCR Assays
      TaqMan Real-Time PCR Assays
    • Antibodies
      Antibodies
    • Oligos, Primers & Probes
      Oligos, Primers & Probes
    • GeneArt Gene Synthesis
      GeneArt Gene Synthesis
    • Cell Culture Plastics
      Cell Culture Plastics
  • 特價商品
  • 聯絡我們
  • 快速訂購
  • 訂單狀態與貨物追蹤
  • 文件和證書
Thermo Fisher Scientific Logo

Search

Search All
Search button
          • 訂單查詢
          • 快速訂購
          • 登入
            登入
            還沒有帳戶嗎 ? 立即註冊
            • 帳戶
            • 訂單
            • Connect: Lab, Data, Apps
            • 客製化產品與項目
            • 儀器管理

          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Synuclein alpha/beta Antibodies

          Bioss

          alpha + beta Synuclein Polyclonal Antibody

          View all (5) Synuclein alpha/beta antibodies

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

          Datasheet
          Protocols
          Questions & Answers
          Tech Support
          Datasheet
          Protocols
          Questions & Answers
          Tech Support
          Datasheet
          Protocols
          Questions & Answers
          Tech Support

          Cite alpha + beta Synuclein Polyclonal Antibody

          • Antibody Testing Data (2)
          alpha + beta Synuclein Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          alpha + beta Synuclein Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

          {{ $ctrl.currentElement.advancedVerification.fullName }}
          {{ $ctrl.currentElement.advancedVerification.text }}

          alpha + beta Synuclein Antibody (BS-0012M) in IHC (P)

          Formalin-fixed and paraffin-embedded rat brain labeled with Mouse Anti-Alpha-Synuclein Polyclonal Antibody, Unconjugated(bs-0012M) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated(bs-0295G-Cy3)used at 1:200 dilution for 40 minutes at 37°C. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          View Product

          {{$ctrl.videoDesc}}

          {{$ctrl.videoLongDesc}}

          alpha + beta Synuclein Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          alpha + beta Synuclein Antibody in Immunohistochemistry (Paraffin) (IHC (P))

          Product Details

          BS-0012M

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:200
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Mouse / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human Alpha-Synuclein.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

          Have you cited this product in a publication?
          Let us know so we can reference it here.
          Cite this product

          Bioinformatics

          Protein Aliases: Alpha-synuclein; Beta-synuclein; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; Phosphoneuroprotein 14; PNP 14; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor)

          View more View less

          Gene Aliases: AI838531; alphaSYN; betaSYN; NACP; PARK1; PARK4; PD1; SNCA; SNCB; Syn

          View more View less

          UniProt ID: (Human) P37840, (Human) Q16143, (Rat) P37377, (Mouse) O55042, (Mouse) Q91ZZ3, (Rat) Q63754

          View more View less

          Entrez Gene ID: (Human) 6622, (Human) 6620, (Rat) 29219, (Mouse) 20617, (Mouse) 104069, (Rat) 113893

          View more View less

          Function(s)
          magnesium ion binding fatty acid binding copper ion binding calcium ion binding protein binding phospholipid binding microtubule binding ferrous iron binding zinc ion binding oxidoreductase activity kinesin binding protein domain specific binding histone binding identical protein binding alpha-tubulin binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process phospholipase binding transcription regulatory region DNA binding dynein binding protein N-terminus binding tau protein binding beta-tubulin binding phosphoprotein binding phospholipase D inhibitor activity phospholipase inhibitor activity enzyme binding Hsp70 protein binding arachidonic acid binding metal ion binding membrane trafficking regulatory protein
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter microglial cell activation positive regulation of receptor recycling negative regulation of protein phosphorylation positive regulation of neurotransmitter secretion fatty acid metabolic process neutral lipid metabolic process phospholipid metabolic process apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process mitochondrial membrane organization aging adult locomotory behavior response to iron(II) ion regulation of phospholipase activity negative regulation of platelet-derived growth factor receptor signaling pathway regulation of glutamate secretion regulation of dopamine secretion negative regulation of microtubule polymerization receptor internalization protein destabilization response to magnesium ion negative regulation of transporter activity response to lipopolysaccharide negative regulation of monooxygenase activity positive regulation of peptidyl-serine phosphorylation response to interferon-gamma cellular response to oxidative stress negative regulation of histone acetylation regulation of locomotion dopamine biosynthetic process response to drug mitochondrial ATP synthesis coupled electron transport regulation of macrophage activation positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process extracellular fibril organization negative regulation of neuron apoptotic process cellular protein metabolic process cellular response to fibroblast growth factor stimulus positive regulation of endocytosis negative regulation of exocytosis negative regulation of dopamine metabolic process behavioral response to cocaine regulation of long-term neuronal synaptic plasticity synaptic vesicle endocytosis synapse organization regulation of acyl-CoA biosynthetic process positive regulation of release of sequestered calcium ion into cytosol dopamine uptake involved in synaptic transmission negative regulation of dopamine uptake involved in synaptic transmission negative regulation of serotonin uptake negative regulation of norepinephrine uptake calcium ion homeostasis oxidation-reduction process excitatory postsynaptic potential long-term synaptic potentiation positive regulation of inositol phosphate biosynthetic process negative regulation of thrombin receptor signaling pathway response to interleukin-1 cellular response to copper ion cellular response to epinephrine stimulus positive regulation of protein serine/threonine kinase activity negative regulation of neuron death negative regulation of mitochondrial electron transport, NADH to ubiquinone positive regulation of glutathione peroxidase activity positive regulation of hydrogen peroxide catabolic process regulation of synaptic vesicle recycling regulation of reactive oxygen species biosynthetic process negative regulation of chaperone-mediated autophagy chemical synaptic transmission dopamine metabolic process negative regulation of catalytic activity synaptic transmission, dopaminergic response to cocaine regulation of neuron apoptotic process regulation of neurotransmitter secretion regulation of neuronal synaptic plasticity synaptic vesicle transport positive regulation of synaptic transmission membrane organization regulation of neuron death regulation of reactive oxygen species metabolic process
          It has to be done as per old AB suggested Products section.
          guarantee_icon

          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

          Learn more
          help_icon

          We're here to help

          Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

          Contact tech support
          產品訂購 Plus Icon Minus Icon
          • 訂單狀態
          • 訂購協助
          • 快速訂購
          • 現貨供應中心
          • 電子採購
          支持 Plus Icon Minus Icon
          • 協助與支持
          • 聯絡我們
          • 技術支持中心
          • 搜尋文件和證書
          • 回報網站問題
          資源 Plus Icon Minus Icon
          • 學習中心
          • 促銷活動
          • 活動和網路研討會
          • 社群媒體
          關於 Thermo Fisher Plus Icon Minus Icon
          • 關於我們 關於我們
          • 人才招募 人才招募
          • 投資者資訊 投資者資訊
          • 新聞 新聞
          • 企業社會責任 企業社會責任
          • 商標
          • 政策和聲明
          品牌 Plus Icon Minus Icon
          • Thermo Scientific
          • Applied Biosystems
          • Invitrogen
          • Gibco
          • Ion Torrent
          • Fisher Scientific
          • Patheon
          • PPD
          • Terms & Conditions
          • Privacy Policy
          • Price & Freight Policy
          © 2006-2026 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
          Taiwan flag icon
          Taiwan

          Your items have has been added!


          Host server : magellan-search-green-55658555d6-xj5mx:80/100.66.79.224:80.
          git-commit: ec8e7df5f8fec8d765bd419205f1b5046a016d37
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.41.0-Offline