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          • Primary Antibodies ›
          • Synuclein alpha/beta Antibodies

          Bioss

          alpha + beta Synuclein Polyclonal Antibody

          View all (6) Synuclein alpha/beta antibodies

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          Cite alpha + beta Synuclein Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (1)
          alpha + beta Synuclein Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          alpha + beta Synuclein Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          alpha + beta Synuclein Antibody (BS-11787R) in IHC (P)

          Paraformaldehyde-fixed, paraffin embedded human glioma; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with alpha + beta Synuclein Antibody, Unconjugated (bs-11787R) at 1:500 overnight at 4°C, followed by a conjugated secondary and DAB stainin... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          View Product

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          alpha + beta Synuclein Antibody in Immunohistochemistry (Paraffin) (IHC (P))

          Product Details

          BS-11787R

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:500
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:100-1:500
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat, Zebrafish

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human alpha + beta Synuclein.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: 41 synuclein; Alpha-synuclein; Beta-synuclein; I(2)-synuclein; I+/--synuclein; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; Phosphoneuroprotein 14; PNP 14; SNCA; SNCB; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor); unnamed protein product; zSyn-β zSynC

          View more View less

          Gene Aliases: AI838531; alphaSYN; betaSYN; NACP; PARK1; PARK4; PD1; SNCA; SNCB; Syn; zgc:66343

          View more View less

          UniProt ID: (Human) P37840, (Human) Q16143, (Rat) P37377, (Mouse) O55042, (Mouse) Q91ZZ3, (Rat) Q63754

          View more View less

          Entrez Gene ID: (Human) 6622, (Human) 6620, (Rat) 29219, (Mouse) 20617, (Mouse) 104069, (Rat) 113893, (Zebrafish) 393944

          View more View less

          Function(s)
          SNARE binding magnesium ion binding transcription regulatory region sequence-specific DNA binding actin binding enzyme inhibitor activity protein kinase inhibitor activity cysteine-type endopeptidase inhibitor activity fatty acid binding copper ion binding calcium ion binding protein binding phospholipid binding microtubule binding enzyme activator activity ferrous iron binding zinc ion binding lipid binding oxidoreductase activity kinesin binding enzyme binding protein domain specific binding Hsp70 protein binding histone binding identical protein binding alpha-tubulin binding phospholipase binding metal ion binding tau protein binding beta-tubulin binding phosphoprotein binding binding, bridging phospholipase D inhibitor activity dynein complex binding protein sequestering activity transporter regulator activity cuprous ion binding phospholipase inhibitor activity transition metal ion binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process dynein binding protein N-terminus binding arachidonic acid binding membrane trafficking regulatory protein
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter microglial cell activation positive regulation of receptor recycling positive regulation of neurotransmitter secretion synaptic transmission, dopaminergic fatty acid metabolic process neutral lipid metabolic process phospholipid metabolic process glutathione metabolic process mitochondrial membrane organization chemical synaptic transmission neurotransmitter secretion adult locomotory behavior response to xenobiotic stimulus response to iron(II) ion negative regulation of platelet-derived growth factor receptor signaling pathway regulation of glutamate secretion regulation of dopamine secretion synaptic vesicle exocytosis synaptic vesicle priming negative regulation of microtubule polymerization receptor internalization protein destabilization response to magnesium ion response to lipopolysaccharide response to interferon-gamma cellular response to oxidative stress SNARE complex assembly positive regulation of SNARE complex assembly regulation of locomotion response to cocaine dopamine biosynthetic process dopamine metabolic process mitochondrial ATP synthesis coupled electron transport regulation of macrophage activation positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of neuron apoptotic process cellular response to fibroblast growth factor stimulus positive regulation of endocytosis negative regulation of exocytosis positive regulation of exocytosis negative regulation of dopamine metabolic process regulation of neurotransmitter secretion behavioral response to cocaine regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity synaptic vesicle endocytosis synaptic vesicle transport positive regulation of inflammatory response positive regulation of synaptic transmission synapse organization regulation of acyl-CoA biosynthetic process protein oligomerization protein tetramerization positive regulation of release of sequestered calcium ion into cytosol neuron apoptotic process dopamine uptake involved in synaptic transmission negative regulation of dopamine uptake involved in synaptic transmission negative regulation of serotonin uptake regulation of norepinephrine uptake negative regulation of norepinephrine uptake calcium ion homeostasis excitatory postsynaptic potential long-term synaptic potentiation positive regulation of inositol phosphate biosynthetic process membrane organization negative regulation of thrombin receptor signaling pathway regulation of microtubule cytoskeleton organization response to interleukin-1 cellular response to copper ion cellular response to epinephrine stimulus fibril organization negative regulation of mitochondrial electron transport, NADH to ubiquinone positive regulation of hydrogen peroxide catabolic process regulation of synaptic vesicle recycling regulation of reactive oxygen species biosynthetic process response to desipramine positive regulation of protein localization to cell periphery negative regulation of chaperone-mediated autophagy regulation of presynapse assembly amyloid fibril formation regulation of reactive oxygen species metabolic process negative regulation of protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process aging regulation of phospholipase activity negative regulation of transporter activity negative regulation of monooxygenase activity positive regulation of peptidyl-serine phosphorylation negative regulation of histone acetylation response to drug negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of neuron apoptotic process oxidation-reduction process positive regulation of protein serine/threonine kinase activity regulation of neuron death positive regulation of glutathione peroxidase activity larval locomotory behavior dopaminergic neuron differentiation
          It has to be done as per old AB suggested Products section.

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