Immunogen sequence: CVIALDRYLA ITSPFRYQSL LTRARARGLV CTVWAISALV SFLPILMHWW RAESDEARRC YNDPKCCDFV TNRAYAIASS VVSFYVPLCI MAFVYLRVFR E; Positive Samples: mouse brain, rat spinal cord
Hepatocyte growth factor receptor (HGF R), a product of the proto-oncogene c-Met, is a heterodimeric transmembrane glycoprotein that is a receptor-type tyrosine kinase. The c-Met heterodimer is composed of an alpha chain that is disulfide-linked to a beta chain. Each alpha and beta subunit heterodimer contain 1152 amino acid residues with a calculated molecular mass of approximately 129 kDa. The alpha chain is exposed to the cell surface and the beta chain spans the plasma membrane. c-Met is synthesized as a single-chain precursor which undergoes cotranslational glycosylation and proteolytic cleavage producing the heterodimeric mature form. Human and mouse HGF receptors share 89% amino acid identity. HGF is the ligand for the HGF receptor.
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Protein Aliases: adrenergic receptor, beta 1; adrenergic, beta-1-, receptor; beta 1-adrenergic receptor beta 1-AR; beta 1-AR; Beta-1 adrenergic receptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor; cardiac beta adrenergic receptor
Gene Aliases: Adrb-1; Adrb1; Adrb1r; B1AR; beta-AR; RATB1AR