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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (KLH conjugated) to the C-terminus.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.7|
|Contains||0.01% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:200|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
OPA1-15267 detects the beta-2 adrenergic receptors from human samples.
OPA1-15267 has been successfully used in immunohistochemistry procedures. By immunohistochemistry, OPA1-15267 detects the beta-2 adrenergic receptors in formalin fixed, paraffin embedded human tissues.
The OPA1-15267 immunogen is a synthetic peptide (KLH conjugated) corresponding to the C-terminus.
Store at 4°C short term. For extended storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
The beta-2 adrenoceptor (ADRB2) is an Adrenergic Receptor expressed in smooth muscle and metabolic tissues. Activation of this receptor induces a decrease in gastrointestinal motility, bronchodilation, vasodilation in skeletal and cardiac muscle, and glycogenolysis in liver. The beta-2 adrenoceptor is also a major lipolytic receptor in human fat cells and may be involved in obesity. Agonists of ADRB2 are most widely used for the treatment of asthma. In complex with beta-arrestin-1 and c-src, the beta-2 adrenergic receptor activates MAP kinases ERK1(MAPK3) and ERK2 (MAPK1). Expression of the beta-2 adrenoceptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel. ESTs have been isolated from breast, liver, liver/spleen, placenta, and uterus libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ADR-beta2; ADR-BetaR; adrenergic, beta-2-, receptor, surface; BAR; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; Beta2AR; catecholamine receptor
ADRB2R; ADRBR; B2AR; BAR; BETA2AR