Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Monkey (100%) Pufferfish, Zebrafish, Stickleback (94%).
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
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Protein Aliases: ADRB2; ADRB2R; ADRBR; Adrenergic beta-2 receptor; adrenergic, beta-2-, receptor, surface; Adrenoceptor beta 2; adrenoceptor beta 2 surface; adrenoceptor beta 2, surface; B2AR; BAR; Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; BETA2AR; Catecholamine receptor; surface
Gene Aliases: ADRB2; ADRB2R; ADRBR; B2AR; BAR; BETA2AR
UniProt ID: (Human) P07550
Entrez Gene ID: (Human) 154