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Invitrogen

beta-2 Adrenergic Receptor Polyclonal Antibody

1 Published Figure
2 References
View all (47) beta-2 Adrenergic Receptor antibodies

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beta-2 Adrenergic Receptor Polyclonal Antibody

Product Details

PA5-86339

Applications
Tested Dilution
Publications

Western Blot (WB)

-
View 1 publication 1 publication

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide, corresponding to amino acids 311-360 of Human AR-beta2.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2803121

Product Specific Information

Multiple bands are observed at 47 kDa,68 kDa (glycosylated), and 95 kDa(Dimer).

Purity is > 95% by SDS-PAGE.

Target Information

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Adrenergic beta 2- receptor surface; adrenergic receptor, beta 2; adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; AR beta2; beta 2-AR; Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; beta2-Adrenoreceptor; catecholamine receptor; HGNC:286; putative; unnamed protein product

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Gene Aliases: Adrb-2; ADRB2; ADRB2R; ADRBR; ARB2; B2AR; Badm; BAR; BETA2AR; Gpcr7

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UniProt ID: (Human) P07550, (Mouse) P18762

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Entrez Gene ID: (Human) 154, (Mouse) 11555, (Rat) 24176

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Function(s)
beta-amyloid binding G-protein coupled receptor activity adrenergic receptor activity beta-adrenergic receptor activity beta2-adrenergic receptor activity protein binding adenylate cyclase binding potassium channel regulator activity enzyme binding identical protein binding protein homodimerization activity macromolecular complex binding norepinephrine binding G-protein alpha-subunit binding signal transducer activity drug binding B2 bradykinin receptor binding protein complex binding dopamine binding ionotropic glutamate receptor binding epinephrine binding PDZ domain binding G-protein coupled receptor
Process(es)
regulation of systemic arterial blood pressure by norepinephrine-epinephrine diet induced thermogenesis vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure regulation of sodium ion transport transcription from RNA polymerase II promoter receptor-mediated endocytosis smooth muscle contraction regulation of smooth muscle contraction signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway endosome to lysosome transport response to cold positive regulation of bone mineralization heat generation negative regulation of multicellular organism growth positive regulation of MAPK cascade bone resorption negative regulation of G-protein coupled receptor protein signaling pathway positive regulation of transcription from RNA polymerase II promoter negative regulation of smooth muscle contraction brown fat cell differentiation positive regulation of mini excitatory postsynaptic potential adrenergic receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway regulation of blood vessel diameter AMPA selective glutamate receptor signaling pathway positive regulation of cold-induced thermogenesis positive regulation of cAMP/PKA signal transduction positive regulation of autophagosome maturation positive regulation of lipophagy cellular response to beta-amyloid response to psychosocial stress desensitization of G-protein coupled receptor protein signaling pathway by arrestin diaphragm contraction positive regulation of the force of heart contraction by epinephrine activation of adenylate cyclase activity cell-cell signaling positive regulation of cell proliferation associative learning positive regulation of sodium ion transport negative regulation of angiogenesis negative regulation of ossification positive regulation of protein ubiquitination positive regulation of ATPase activity synaptic transmission, glutamatergic negative regulation of urine volume wound healing regulation of vasodilation positive regulation of apoptotic process positive regulation of potassium ion transport positive regulation of heart contraction positive regulation of vasodilation positive regulation of skeletal muscle tissue growth negative regulation of inflammatory response regulation of calcium ion transport regulation of sensory perception of pain excitatory postsynaptic potential cellular response to hypoxia negative regulation of platelet aggregation mitophagy in response to mitochondrial depolarization response to hypoxia liver development female pregnancy aging response to progesterone response to testosterone response to estrogen estrous cycle response to dexamethasone response to monoamine liver regeneration
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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