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Invitrogen
beta-2 Defensin Polyclonal Antibody
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Product Details
PA5-107328
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHPVFCPRRYKQIGTCGL
Conjugate
Form
Liquid
Concentration
100 µg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Product is supplied at 1 mL (100 µL/mL).
Application Notes: Western Blot - Test was performend under reduced sample treatment using SDS-Page. The band size is 25kDa for recombinant protein with tag and 5 kDa for the native protein. IHC-P- Tissue sections were pretreated with high temperature citrate and fixed in formalin. PBS was used as a negative control.
Target Information
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, six human beta-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BD-2; beta defensin-2; Beta-defensin 2; beta-defensin 4A; Defensin beta 2; Defensin beta 4A; Defensin beta2; Defensin, beta 2; defensin, beta 4; Defensin-beta2; SAP1; Skin-antimicrobial peptide 1
Gene Aliases: BD-2; DEFB-2; DEFB102; DEFB2; DEFB4; DEFB4A; DEFB4B; HBD-2; SAP1
UniProt ID: (Human) O15263
Entrez Gene ID: (Human) 1673
chemotaxis
defense response
immune response
G-protein coupled receptor signaling pathway
killing of cells of other organism
defense response to bacterium
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
defense response to fungus
positive chemotaxis
cell chemotaxis
antifungal innate immune response
antimicrobial humoral immune response mediated by antimicrobial peptide
defense response to symbiont
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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