Search

  • Contact Us
  • Quick Order

Invitrogen

beta-2 Microglobulin Polyclonal Antibody

Advanced Verification
1 Published Figure
1 Reference
View all (80) beta-2 Microglobulin antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
beta-2 Microglobulin Polyclonal Antibody

Product Details

PA5-29580

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

Immunoprecipitation (IP)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Full length human beta 2 Microglobulin Recombinant protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 1% BSA, 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2547056

Product Specific Information

Recommended positive controls: A431, mouse plasma, rat plasma, HeLa, B2M shRNA-transfected HeLa, marmoset rProtein.

Predicted reactivity: Rhesus Monkey (92%), Chimpanzee (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: B-F; B2-microglobulin; B2M; Beta 2 microglobin; Beta 2 microglobulin; beta 2-microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; Beta-2-microglobulin; beta-2-microglobulin C-terminal fragment (55 AA); Beta2 microglobulin; HDCMA22P; MHC Class I; microglobulin beta-2; Orla-B2m; similar to Homo sapiens mRNA for beta 2-microglobulin with GenBank Accession Number AB021288; unnamed protein product

View more View less

Gene Aliases: AMYLD6; B2M; beta2-m; beta2m; CDABP0092; HDCMA22P; IMD43; Ly-m11; MHC1D4

View more View less

UniProt ID: (Human) P61769, (Mouse) P01887, (Rat) P07151

View more View less

Entrez Gene ID: (Human) 567, (Mouse) 12010, (Rat) 24223

View more View less

Function(s)
structural molecule activity protein binding MHC class II protein complex binding peptide antigen binding identical protein binding protein homodimerization activity glycoprotein binding molecular_function major histocompatibility complex protein
Process(es)
T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity response to molecule of bacterial origin immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent peptide antigen assembly with MHC class I protein complex peptide antigen assembly with MHC class II protein complex positive regulation of T cell cytokine production regulation of membrane depolarization iron ion transport cellular iron ion homeostasis immune response sensory perception of smell learning or memory response to metal ion negative regulation of neuron projection development antibacterial humoral response antigen processing and presentation of endogenous peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen via MHC class II T cell differentiation in thymus transferrin transport regulation of iron ion transport negative regulation of iron ion transport protein refolding innate immune response regulation of erythrocyte differentiation positive regulation of receptor-mediated endocytosis negative regulation of receptor-mediated endocytosis negative regulation of epithelial cell proliferation negative regulation of neurogenesis positive regulation of immune response defense response to Gram-negative bacterium defense response to Gram-positive bacterium positive regulation of T cell activation protein homotetramerization multicellular organismal iron ion homeostasis antimicrobial humoral immune response mediated by antimicrobial peptide cellular response to lipopolysaccharide cellular response to iron ion cellular response to iron(III) ion cellular response to nicotine amyloid fibril formation positive regulation of cellular senescence negative regulation of forebrain neuron differentiation cellular defense response iron ion homeostasis negative regulation of receptor binding retina homeostasis response to drug response to cadmium ion
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support