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Invitrogen
beta-2 Microglobulin Polyclonal Antibody
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FIGURE: 1 / 16
beta-2 Microglobulin Antibody (PA5-29580) in ICC/IF
beta-2 Microglobulin Polyclonal Antibody detects beta 2 Microglobulin protein by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: beta 2 Microglobulin stained by beta-2 Microglobulin Polyclonal Antibody (Product # PA5-29580) diluted at 1:500. Blue: Fluoroshield with DAPI .
Product Details
PA5-29580
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length human beta 2 Microglobulin Recombinant protein.
Conjugate
Form
Liquid
Concentration
0.37 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: A431, mouse plasma, rat plasma, HeLa, B2M shRNA-transfected HeLa, marmoset rProtein.
Predicted reactivity: Rhesus Monkey (92%), Chimpanzee (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B-F; B2-microglobulin; Beta 2 microglobin; Beta 2 microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; Beta-2-microglobulin; beta-2-microglobulin C-terminal fragment (55 AA); Beta2 microglobulin; MHC Class I; microglobulin beta-2; Orla-B2m
Gene Aliases: B2M; beta2-m; beta2m; CDABP0092; HDCMA22P; IMD43; Ly-m11
UniProt ID: (Human) P61769, (Mouse) P01887, (Rat) P07151
Entrez Gene ID: (Human) 567, (Mouse) 12010, (Rat) 24223
retina homeostasis
positive regulation of T cell mediated cytotoxicity
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
positive regulation of T cell cytokine production
regulation of membrane depolarization
negative regulation of neuron projection development
antibacterial humoral response
antigen processing and presentation of endogenous peptide antigen via MHC class I
positive regulation of protein binding
T cell differentiation in thymus
protein refolding
response to drug
cellular protein metabolic process
innate immune response
response to cadmium ion
positive regulation of receptor-mediated endocytosis
regulation of defense response to virus by virus
regulation of immune response
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
iron ion homeostasis
interferon-gamma-mediated signaling pathway
cellular response to lipopolysaccharide
cellular response to iron ion
negative regulation of receptor binding
positive regulation of receptor binding
positive regulation of ferrous iron import into cell
positive regulation of ferrous iron binding
positive regulation of transferrin receptor binding
response to molecule of bacterial origin
immune system process
cellular defense response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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