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Invitrogen

beta-2 Microglobulin Polyclonal Antibody

View all (98) beta-2 Microglobulin antibodies

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beta-2 Microglobulin Polyclonal Antibody

Product Details

PA5-95426

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-

Immunocytochemistry (ICC/IF)

2 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/1x10^6 cells
-

ELISA (ELISA)

1-5 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived human Beta 2 Microglobulin recombinant protein (Position: Q22-M119).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2807229

Product Specific Information

Human Beta 2 Microglobulin shares 69.4% and 74.5% amino acid (aa) sequence identity with mouse and rat Beta 2 Microglobulin, respectively.

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human U251 whole cell, human THP-1 whole cell, human Hela whole cell, human A431 whole cell. IHC: human intestinal cancer tissue, human lung cancer tissue. ICC/IF: A431 cell, A431 cell. Flow: U251 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B-F; B2-microglobulin; B2M; Beta 2 microglobin; Beta 2 microglobulin; beta 2-microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; Beta-2-microglobulin; Beta2 microglobulin; HDCMA22P; MHC Class I; microglobulin beta-2; Orla-B2m; similar to Homo sapiens mRNA for beta 2-microglobulin with GenBank Accession Number AB021288; unnamed protein product

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Gene Aliases: AMYLD6; B2M; CDABP0092; HDCMA22P; IMD43; MHC1D4

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UniProt ID: (Human) P61769

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Entrez Gene ID: (Human) 567

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Function(s)
structural molecule activity protein binding MHC class II protein complex binding peptide antigen binding identical protein binding protein homodimerization activity
Process(es)
T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity response to molecule of bacterial origin immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent peptide antigen assembly with MHC class I protein complex peptide antigen assembly with MHC class II protein complex positive regulation of T cell cytokine production regulation of membrane depolarization iron ion transport cellular iron ion homeostasis immune response sensory perception of smell learning or memory response to metal ion negative regulation of neuron projection development antibacterial humoral response antigen processing and presentation of endogenous peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen via MHC class II T cell differentiation in thymus transferrin transport regulation of iron ion transport negative regulation of iron ion transport protein refolding innate immune response regulation of erythrocyte differentiation positive regulation of receptor-mediated endocytosis negative regulation of receptor-mediated endocytosis negative regulation of epithelial cell proliferation negative regulation of neurogenesis positive regulation of immune response defense response to Gram-negative bacterium defense response to Gram-positive bacterium positive regulation of T cell activation protein homotetramerization multicellular organismal iron ion homeostasis antimicrobial humoral immune response mediated by antimicrobial peptide cellular response to lipopolysaccharide cellular response to iron ion cellular response to iron(III) ion cellular response to nicotine amyloid fibril formation positive regulation of cellular senescence negative regulation of forebrain neuron differentiation
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