Immunogen sequence: MAPWPHENSS LAPWPDLPTL APNTANTSGL PGVPWEAALA GALLALAVLA TVGGNLLVIV AIAWTPRLQT MTNVFVTSLA AADLVMGLLV VPPAATLALT; Positive Samples: HL-60, K-562; Cellular Location: Cell membrane, Multi-pass membrane protein
beta 3 Adrenergic Receptor is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Beta adrenergic receptors are involved in the epinephrine and norepinephrine-induced activation of adenylate cyclase through the action of G proteins. beta 3 Adrenergic Receptor expression has been documented in adipose tissues, heart, and in smooth muscle of digestive and urinary tract organs (bladder, colon, small intestine, stomach, ureter). Utilization of alternate promoters and/or 3-prime untranslated regions may result in tissue-specific regulation of the expression of this protein.
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Protein Aliases: adrenergic receptor, beta 3; adrenergic, beta-3-, receptor; beta 3 adrenoceptor; beta 3-AR; Beta-3 adrenergic receptor; Beta-3 adrenoceptor; Beta-3 adrenoreceptor; Beta-3 AR; beta3-adrenergic receptor; beta3-Adrenoreceptor; Beta3-AR; FLJ99960
Gene Aliases: ADRB; Adrb-3; ADRB3; ADRB3R; B3AR; B3bar; BETA3AR
Molecular Function: G-protein coupled receptor