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beta-Actin Polyclonal Antibody

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beta-Actin Polyclonal Antibody

Product Details

BS-0061R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:200
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

All, Bovine, Dog, Goat, Human, Mouse, Sheep, Pig, Rabbit, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MAP conjugated synthetic peptide derived from human beta Actin, amino acids 1-200.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Beta actin is one of six actin isoforms which have been identified. Beta actin is a non-muscle cytoskeletal protein in all human cell types and is involved in cell motility, structure, and integrity. There are six different actin isoforms in human. The beta isoform of actin, along with gamma actin, coexist in most cell types as components of the cyto-skeleton. Beta actins are cytoplasmic proteins ubuquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of two stranded helix. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Because beta actin is ubiquitously expressed in all eukaryotic cells, it is frequently used as a loading control for assays involving protein detection, such as Western blotting. Antibodies to beta-actin provide a specific and useful tool in studying the intracellular distribution of beta-actin and the static and dynamic aspects of the cytoskeleton.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Actin is a protein with a high degree of evolutionary conservation that undergoes polymerization to generate filaments, which subsequently assemble into interconnected networks within the cytoplasm of cells.; Actin, cytoplasmic 1; beta actin; beta cytoskeletal actin; Beta-actin; cytoplasmic beta-actin; cytoskeletal beta actin; gamma non-muscle actin; I(2)-actin; PS1TP5-binding protein 1; unnamed protein product

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Gene Aliases: ACT-5; ACTB; Actx; beta-actin; BKRNS; BNS; BRWS1; CSMH; DDS1; E430023M04Rik; PS1TP5BP1; THC8

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UniProt ID: (Sheep) P60713, (Rabbit) P29751, (Bovine) P60712, (Pig) Q6QAQ1, (Human) P60709, (Dog) O18840, (Rat) P60711, (Mouse) P60710

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Entrez Gene ID: (Sheep) 443052, (Rabbit) 100009272, (Bovine) 280979, (Goat) 102179831, (Pig) 414396, (Human) 60, (Dog) 403580, (Rat) 81822, (Mouse) 11461

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Function(s)
protein binding ATP binding kinesin binding Tat protein binding identical protein binding nitric-oxide synthase binding nucleotide binding structural constituent of cytoskeleton hydrolase activity ATPase activity protein kinase binding nitric-oxide synthase regulator activity nucleosomal DNA binding tau protein binding structural constituent of postsynaptic actin cytoskeleton transporter regulator activity RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding actin and actin related protein actin or actin-binding cytoskeletal protein cytoskeletal protein
Process(es)
morphogenesis of a polarized epithelium establishment or maintenance of cell polarity regulation of transmembrane transporter activity negative regulation of protein binding adherens junction assembly apical protein localization synaptic vesicle endocytosis regulation of norepinephrine uptake protein localization to adherens junction cellular response to cytochalasin B postsynaptic actin cytoskeleton organization regulation of protein localization to plasma membrane chromatin remodeling regulation of transcription from RNA polymerase II promoter cytoskeleton organization axonogenesis positive regulation of cell proliferation substantia nigra development regulation of mitotic metaphase/anaphase transition maintenance of blood-brain barrier regulation of apoptotic process positive regulation of T cell differentiation negative regulation of cell differentiation positive regulation of cell differentiation positive regulation of myoblast differentiation positive regulation of transcription, DNA-templated cell motility positive regulation of norepinephrine uptake regulation of cell cycle regulation of G0 to G1 transition platelet aggregation regulation of transepithelial transport regulation of synaptic vesicle endocytosis positive regulation of stem cell population maintenance positive regulation of double-strand break repair via homologous recombination regulation of G1/S transition of mitotic cell cycle regulation of double-strand break repair positive regulation of double-strand break repair regulation of nucleotide-excision repair retina homeostasis ATP-dependent chromatin remodeling retina development in camera-type eye cellular response to electrical stimulus
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