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      View (44) other beta Amyloid antibodies

      Invitrogen

      beta Amyloid (1-40) Polyclonal Antibody

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      Catalog #:44-136

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      Product Details

      TESTED APPLICATIONS DILUTION
      Dot blot (DB) Assay Dependent
      ELISA (ELISA) 1µg/ml
      Immunohistochemistry (IHC) Assay Dependent
      Radioimmune Assays (RIA) Assay Dependent
      PUBLISHED APPLICATIONS
      Western Blot (WB) See 4 publications below
      Immunohistochemistry (Frozen) (IHC (F)) See 1 publications below
      Immunofluorescence (IF) See 1 publications below
      Immunohistochemistry (IHC) See 1 publications below
      Immunohistochemistry - Free Floating (IHC (Free)) See 1 publications below
      Immunoprecipitation (IP) See 1 publications below
      Immunohistochemistry (Paraffin, Frozen) (IHC (P, F)) See 1 publications below
      ELISA (ELISA) See 1 publications below
      Tested Species reactivity Human
      Published species reactivity Human , Mouse
      Host / Isotype Rabbit / IgG
      Class Polyclonal
      Type Antibody
      Immunogen The antiserum was produced against a chemically synthesized peptide corresponding to amino acids 1-40 of human beta-Amyloid (A-beta).
      Conjugate Unconjugated
      Form Liquid
      Concentration 0.5 mg/ml
      Purification Antigen affinity chromatography
      Storage buffer Dulbecco's PBS, pH 7.3
      Contains no preservative
      Storage conditions -80°C
      RRID AB_2533599

      Product Specific Information

      No significant cross-reactivity to beta-Amyloid 42 has been observed. Previous lots of this antibody recognized the sequence of beta-Amyloid [1-40] in the region from amino acids 15-30. No blocking activity was observed with beta-Amyloid [1-12] whereas the peptides beta-Amyloid [14-35], beta-Amyloid [15-28], beta-Amyloid [17-30] and Beta-Amyloid [1-40] were all able to block antibody activity.

      Background/Target Information

      Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer and quote;s disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE). This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components. Found associated with the presenilins is the transmembrane glycoprotein nicastrin. Nicastrin has been found to bind to the carboxyl-terminus of betaAPP and helps to modulate the production of the amyloid beta peptide.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      References (11)

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      Bioinformatics

      Protein Aliases: AAA; ABETA; ABPP; AD1; Alzheimer disease amyloid protein; amyloid beta (A4) precursor protein; Amyloid beta A4 protein; Amyloid precursor protein; Amyloidogenic glycoprotein AG; APP; APPI; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); Beta-amyloid precursor protein; Cerebral vascular amyloid peptide; CTFgamma; CVAP; Peptidase nexin-II; PN-II; PN2; PreA4; Protease nexin-II; testicular tissue protein Li 2

      Gene Aliases: A4; AAA; ABETA; ABPP; AD1; APP; APPI; CTFgamma; CVAP; PN-II; PN2

      UniProt ID: (Human) B4DII8

      Entrez Gene ID: (Human) 351

      Molecular Function: signaling molecule

      Function(s) Blue Arrow Icon
      response to yeast suckling behavior platelet degranulation mRNA polyadenylation regulation of translation protein phosphorylation cellular copper ion homeostasis endocytosis response to oxidative stress cell adhesion regulation of epidermal growth factor-activated receptor activity Notch signaling pathway axonogenesis mating behavior locomotory behavior axo-dendritic transport cholesterol metabolic process adult locomotory behavior visual learning cellular process response to lead ion negative regulation of endopeptidase activity positive regulation of peptidase activity positive regulation of G2/M transition of mitotic cell cycle axon midline choice point recognition neuron remodeling dendrite development antibacterial humoral response antifungal humoral response extracellular matrix organization forebrain development neuron projection development ionotropic glutamate receptor signaling pathway regulation of multicellular organism growth regulation of protein binding cellular protein metabolic process innate immune response negative regulation of neuron differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter collateral sprouting in absence of injury regulation of synapse structure or activity defense response to Gram-negative bacterium defense response to Gram-positive bacterium neuromuscular process controlling balance synaptic growth at neuromuscular junction neuron apoptotic process smooth endoplasmic reticulum calcium ion homeostasis cellular response to cAMP cellular response to norepinephrine stimulus amyloid fibril formation cellular response to nerve growth factor stimulus
      Process(es) Blue Arrow Icon
      DNA binding
       serine-type endopeptidase inhibitor activity
       receptor binding
       protein binding
       heparin binding
       peptidase activator activity
       enzyme binding
       identical protein binding
       transition metal ion binding
       PTB domain binding
       growth factor receptor binding

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