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|Tested species reactivity||Human , Mouse , Rat , Porcine|
|Published species reactivity||Rat , Human , Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 22 amino acid synthetic peptide derived from the C-terminus of the human beta-amyloid precursor protein (beta-APP). This sequence is 100% conserved in human, monkey, mouse, rat, guinea pig, and chicken beta-APP proteins.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||0.1-1.0 ug/ml|
|Immunofluorescence (IF)||1-5 ug/ml|
|Immunohistochemistry (IHC)||0.1-1.0 ug/ml|
|Western Blot (WB)||0.2-2 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 8 publications below|
|Immunohistochemistry (Frozen) (IHC (F))||See 6 publications below|
|Immunocytochemistry (ICC)||See 1 publications below|
|Western Blot (WB)||See 8 publications below|
|Immunohistochemistry - Free Floating (IHC (Free))||See 1 publications below|
Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer"e;s disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE). This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components. Found associated with the presenilins is the transmembrane glycoprotein nicastrin. Nicastrin has been found to bind to the carboxyl-terminus of betaAPP and helps to modulate the production of the amyloid beta peptide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
A novel closed-body model of spinal cord injury caused by high-pressure air blasts produces extensive axonal injury and motor impairments.
51-2700 was used in immunohistochemistry to describe the development of a closed-body model of spinal cord injury in mice
|del Mar N,von Buttlar X,Yu AS,Guley NH,Reiner A,Honig MG||Experimental neurology (271:53)||2015|
Experimental traumatic brain injury induces rapid aggregation and oligomerization of amyloid-beta in an Alzheimer's disease mouse model.
51-2700 was used in immunohistochemistry to study Abeta agggregation and oligomerization induced in a murine model of Alzheimer's disease by experimental traumatic brain injury
|Washington PM,Morffy N,Parsadanian M,Zapple DN,Burns MP||Journal of neurotrauma (31:125)||2014|
Secondary damage caused by CD11b+ microglia following diffuse axonal injury in rats.
51-2700 was used in immunohistochemistry to investigate diffuse axonal injury.
|Jia X,Cong B,Wang S,Dong L,Ma C,Li Y||The journal of trauma and acute care surgery (73:1168)||2012|
Increased intracranial pressure after diffuse traumatic brain injury exacerbates neuronal somatic membrane poration but not axonal injury: evidence for primary intracranial pressure-induced neuronal perturbation.
51-2700 was used in immunohistochemistry to study the neuronal somatic and axonal damage that occurs during elevated intracranial pressure.
|Lafrenaye AD,McGinn MJ,Povlishock JT||Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (32:1919)||2012|
Temporal assessment of traumatic axonal injury in the rat corpus callosum and optic chiasm.
51-2700 was used in immunohistochemistry to perform a time course to study impaired axoplasmic transport and neurofilament compaction.
|Zakaria N,Kallakuri S,Bandaru S,Cavanaugh JM||Brain research (1467:81)||2012|
Internal jugular vein compression mitigates traumatic axonal injury in a rat model by reducing the intracranial slosh effect.
51-2700 was used in immunohistochemistry to discuss the use of helmets to prevent traumatic brain injury.
|Smith DW,Bailes JE,Fisher JA,Robles J,Turner RC,Mills JD||Neurosurgery (70:740)||2012|
Quantitative relationship between axonal injury and mechanical response in a rodent head impact acceleration model.
51-2700 was used in immunohistochemistry to study traumatic axonal injury in rats.
|Li Y,Zhang L,Kallakuri S,Zhou R,Cavanaugh JM||Journal of neurotrauma (28:1767)||2011|
Evolution of a neuroprotective function of central nervous system myelin.
||Yin X,Baek RC,Kirschner DA,Peterson A,Fujii Y,Nave KA,Macklin WB,Trapp BD||The Journal of cell biology (172:469)||2006|
Neurotransmitter Systems in a Mild Blast Traumatic Brain Injury Model: Catecholamines and Serotonin.
51-2700 was used in immunohistochemistry - frozen section to examine the role of the monoaminergic system in mild blast-induced traumatic brain injury.
|Kawa L,Arborelius UP,Yoshitake T,Kehr J,Hökfelt T,Risling M,Agoston D||Journal of neurotrauma (32:1190)||2015|
Array tomography for the detection of non-dilated, injured axons in traumatic brain injury.
51-2700 was used in immunohistochemistry - frozen section to discuss the limitations assessing axonal injury by microscopy
|Bennett RE,Brody DL||Journal of neuroscience methods (245:25)||2015|
Acute reduction of microglia does not alter axonal injury in a mouse model of repetitive concussive traumatic brain injury.
51-2700 was used in immunohistochemistry - frozen section to study the contribution of microglia to axon degeneration after repetitive closed-skull traumatic brain injury using CD11b-thymidine kinase mice
|Bennett RE,Brody DL||Journal of neurotrauma (31:1647)||2014|
Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain.
51-2700 was used in immunohistochemistry - frozen section to assess temporal and spatial onset of the reactive glia response in a clinically relevant form of Pelizaeus-Merzbacher disease.
|Bachstetter AD,Webster SJ,Van Eldik LJ,Cambi F||Journal of neuroinflammation (10:null)||2013|
Rodent model of direct cranial blast injury.
51-2700 was used in immunohistochemistry - frozen section to characterize a rodent model of direct cranial blast injury.
|Kuehn R,Simard PF,Driscoll I,Keledjian K,Ivanova S,Tosun C,Williams A,Bochicchio G,Gerzanich V,Simard JM||Journal of neurotrauma (28:2155)||2011|
A mouse model of blast injury to brain: initial pathological, neuropathological, and behavioral characterization.
51-2700 was used in immunohistochemistry - frozen section to investigate the effects of blast injury on the parenchymatous organs of mice.
|Koliatsos VE,Cernak I,Xu L,Song Y,Savonenko A,Crain BJ,Eberhart CG,Frangakis CE,Melnikova T,Kim H,Lee D||Journal of neuropathology and experimental neurology (70:399)||2011|
TREM2 regulates microglial cell activation in response to demyelination in vivo.
51-2700 was used in immunocytochemistry to investigate the contribution of TREM2 to microglia function in vivo
|Cantoni C,Bollman B,Licastro D,Xie M,Mikesell R,Schmidt R,Yuede CM,Galimberti D,Olivecrona G,Klein RS,Cross AH,Otero K,Piccio L||Acta neuropathologica (129:429)||2015|
Fragile X mental retardation protein expression in Alzheimer's disease.
51-2700 was used in western blot to identify the relation between fragile X mental retardation protein and Alzheimer disease
|Renoux AJ,Carducci NM,Ahmady AA,Todd PK||Frontiers in genetics (5:null)||2014|
Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.
51-2700 was used in western blot to discuss the effects of BMS-869780, a gamma secretase inhibitor, in several animal models
|Toyn JH,Thompson LA,Lentz KA,Meredith JE,Burton CR,Sankaranararyanan S,Guss V,Hall T,Iben LG,Krause CM,Krause R,Lin XA,Pierdomenico M,Polson C,Robertson AS,Denton RR,Grace JE,Morrison J,Raybon J,Zhuo X,Snow K,Padmanabha R,Agler M,Esposito K,Harden D,Prack M,Varma S,Wong V,Zhu Y,Zvyaga T,Gerritz S,Marcin LR,Higgins MA,Shi J,Wei C,Cantone JL,Drexler DM,Macor JE,Olson RE,Ahlijanian MK,Albright CF||International journal of Alzheimer's disease (2014:null)||2014|
Myelin loss and oligodendrocyte pathology in white matter tracts following traumatic brain injury in the rat.
51-2700 was used in western blot to assess myelin loss and oligodendrocyte death following traumatic brain injury.
|Flygt J,Djupsjö A,Lenne F,Marklund N||The European journal of neuroscience (38:2153)||2013|
Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice.
||Westmark CJ,Westmark PR,O'Riordan KJ,Ray BC,Hervey CM,Salamat MS,Abozeid SH,Stein KM,Stodola LA,Tranfaglia M,Burger C,Berry-Kravis EM,Malter JS||PloS one (6:null)||2011|
Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress.
51-2700 was used in western blot to study the mechanism by which behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice.
|Lee KW,Kim JB,Seo JS,Kim TK,Im JY,Baek IS,Kim KS,Lee JK,Han PL||Journal of neurochemistry (108:165)||2009|
Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease.
51-2700 was used in western blot to investigate the regulatory link between beta-amyloid precursor protein and dual-specificity tyrosine(Y)-phosphorylation regulated kinase A in Down syndrome brains.
|Ryoo SR,Cho HJ,Lee HW,Jeong HK,Radnaabazar C,Kim YS,Kim MJ,Son MY,Seo H,Chung SH,Song WJ||Journal of neurochemistry (104:1333)||2008|
Ginkgo biloba extract (Egb 761) inhibits beta-amyloid production by lowering free cholesterol levels.
||Yao ZX,Han Z,Drieu K,Papadopoulos V||The Journal of nutritional biochemistry (15:749)||2004|
Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.
||Ghersi E,Noviello C,D'Adamio L||The Journal of biological chemistry (279:49105)||2004|
Moderately elevated intracranial pressure after diffuse traumatic brain injury is associated with exacerbated neuronal pathology and behavioral morbidity in the rat.
51-2700 was used in immunohistochemistry - free floating to assess if subischemic levels of elevated intracranial pressure without hematoma/contusion contribute to increased morbidity/mortality
|Lafrenaye AD,Krahe TE,Povlishock JT||Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (34:1628)||2014|
PN-II, CVAP, E030013M08Rik, ABETA, ABPP, CTFgamma, PN2, Ag, AAA, Abeta, betaApp, Abpp, APPI, Adap, Cvap, AD1
ABPP, AG, alzheimer disease amyloid A4 protein homolog, amyloid A4, amyloid beta A4 protein, amyloidogenic glycoprotein, alzheimer disease amyloid protein, beta-amyloid peptide, cerebral vascular amyloid peptide, peptidase nexin-II, preA4, protease nexin-II, appican, protease nexin II, amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease), amyloid precursor protein, AAA, ABETA, AD1, CTFgamma, CVAP, PN2, APP, Amyloidogenic glycoprotein AG, Amyloid beta A4 protein, amyloid beta (A4) precursor protein, Peptidase nexin-II