Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
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Protein Aliases: ARB2; ARR2; ARRB2; arrestin 3; arrestin beta 2; Arrestin beta-2; arrestin, beta 2; BARR2; beta arr2; beta-arrestin 2; Beta-arrestin-2; DKFZp686L0365; HGNC:712; Non-visual arrestin-3
Gene Aliases: AI326910; ARB2; ARR2; ARRB2; AW122872; BARR2; BARRES