PA1-068 detects coatomer-protein I beta' (COPI beta) from rat cells.
PA1-068 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~115 kDa protein representing COP beta from PC-12 cell extract. A non-specific band at ~100 kDa may be seen.
PA1-068 immunogen is a synthetic peptide corresponding to residues K(494) V L A A Q E T H E G V T E D G I E(511) of rat beta-COP. The PA1-068 immunizing peptide (Cat. # PEP-126) is available for use in neutralization and control experiments.
This gene encodes a protein subunit of the coatomer complex associated with non-clathrin coated vesicles. The coatomer complex, also known as the coat protein complex 1, forms in the cytoplasm and is recruited to the Golgi by activated guanosine triphosphatases. Once at the Golgi membrane, the coatomer complex may assist in the movement of protein and lipid components back to the endoplasmic reticulum. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Beta-coat protein; Beta-COP; Coatomer subunit beta; DKFZp761K102; FLJ10341; FLJ46444; FLJ57957; receptor for activated C-kinase-2
Gene Aliases: Copb; Copb1; Rack2
UniProt ID: (Rat) P23514
Entrez Gene ID: (Rat) 114023