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Invitrogen
c-Fos Polyclonal Antibody
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Product Details
PA1-18329
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rabbit,
Rat
Published species
Rat
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the N-terminal residues M(2) F S G F N A D Y E A S S S R C(17).
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
500 µg
Purification
Protein G
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Target Information
FBJ murine osteosarcoma viral oncogene homolog is commonly known as Cellular protooncogene Fos (c-Fos). It belongs to the fos transcription factor family and is encoded by the C-FOS gene located on chromosome 14. c-Fos heterodimerizes with c-Jun to form the Activator Protein -1 (AP-1) transcription factor which regulates transcription of several genes that play an important role in cellular signal transduction, cell proliferation and differentiation. c-Fos has been shown to be phosphorylated by various stimuli including growth factors and insulin at atleast seven different sites. The best known upstream kinase for phosphorylation at Threonine 232 is ERK MAPK which regulates localization of c-Fos to the nucleus and is thus important for c-Fos induced transcriptional activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: c-fos oncogene; Cellular oncogene fos; FBJ murine osteosarcoma viral oncogene homolog; Protein c-Fos; Proto-oncogene c-Fos; proto-oncogene cFOS; v-fos FBJ murine osteosarcoma viral oncogene homolog
Gene Aliases: c-fos; Fos
UniProt ID: (Rat) P12841
Entrez Gene ID: (Rabbit) 100338345, (Rat) 314322
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
R-SMAD binding
basic leucine zipper transcription factor
conditioned taste aversion
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
nervous system development
female pregnancy
aging
response to cold
response to light stimulus
response to mechanical stimulus
response to gravity
response to toxic substance
response to organic cyclic compound
sleep
cellular response to extracellular stimulus
response to lipopolysaccharide
response to progesterone
cellular response to hormone stimulus
response to cytokine
cellular response to reactive oxygen species
response to immobilization stress
skeletal muscle cell differentiation
response to muscle stretch
response to drug
positive regulation of osteoclast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to corticosterone
response to cAMP
SMAD protein signal transduction
cellular response to calcium ion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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