|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||MOLM-1 megakaryocytic cells|
|Storage buffer||PBS, pH 7.2, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 2 publications below|
Allophycocyanin (APC) is a stable and highly soluble phycobiliprotein that provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing exceptional quantum yields and molar extinction coefficients.
c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activation of the Ras-Raf-ERK1 and 2 signaling pathway.
Analyte Specific Reagent
Generation of polyhormonal and multipotent pancreatic progenitor lineages from human pluripotent stem cells.
CD11705 was used in flow cytometry to describe protocols to generate specific pancreatic lineages from hPSCs
|Korytnikov R,Nostro MC||Methods (San Diego, Calif.) (101:56)||2016|
SOX17 is a critical specifier of human primordial germ cell fate.
CD11705 was used in flow cytometry to identify SOX17 as a key regulator of human primordial germ cell fate.
|Irie N,Weinberger L,Tang WW,Kobayashi T,Viukov S,Manor YS,Dietmann S,Hanna JH,Surani MA||Cell (160:253)||2015|