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Invitrogen
c-Met Polyclonal Antibody
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FIGURE: 1 / 1
c-Met Antibody (PA5-117533) in WB
Western Blot analysis of c-Met using c-Met Polyclonal Antibody (Product # PA5-117533) at 2 µg/mL. Positive WB detected in Recombinant protein. Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 42 kDa. Observed band size: 52 kDa
Product Details
PA5-117533
Product Specifications
Species Reactivity
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Zebrafish MET proto-oncogene, receptor tyrosine kinase protein (76-179aa)
Conjugate
Form
Liquid
Concentration
2.014 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody has been tested in direct-ELISA
Target Information
MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cMet; D249; EC 2.7.10.1; HGF-SF receptor; met proto-oncogene (hepatocyte growth factor receptor); oncogene MET; sc MET; soluble c met
Gene Aliases: c-met; cmet
Entrez Gene ID: (Zebrafish) 100150664
neuron migration
liver development
protein phosphorylation
phagocytosis
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
nervous system development
phosphorylation
cell migration
spinal cord motor neuron differentiation
cerebellum development
cerebellum morphogenesis
cerebellar granule cell differentiation
central nervous system neuron differentiation
neuron differentiation
pancreas development
exocrine pancreas development
pectoral fin development
positive regulation of kinase activity
positive regulation of protein kinase B signaling
semaphorin-plexin signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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