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Bethyl Laboratories
c-Rel Polyclonal Antibody
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FIGURE: 1 / 2
c-Rel Antibody (A301-826A) in WB
Detection of human c-Rel by western blot. Samples: Whole cell lysate from HeLa (50, 15, 5 µg) and HEK293T (T; 50 µg) cells. Antibodies: Affinity purified rabbit anti-c-Rel antibody (Product # A301-826A) (lot A301-826A-1) used for WB at 0.4 µg/mL. Detection: Chemiluminescence with exposure time of 30 seconds.
Product Details
A301-826A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 569 and 619 of human reticuloendotheliosis viral oncogene homolog.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA., RELB (604758), NFKB1, and NFKB2. These proteins are related through a highly conserved N-terminal region termed the 'Rel domain, ' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (Belguise and Sonenshein, 2007).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BCD541; c-rel; C-Rel protein; gemin 1; gemin-1; oncogene REL, avian reticuloendotheliosis; Proto-oncogene c-Rel; SMA; SMA1; SMA2; SMA3; SMA4; SMN; SMN2; SMNT; unnamed protein product; v-rel avian reticuloendotheliosis viral oncogene homolog
Gene Aliases: C-Rel; HIVEN86A; IMD92; REL
UniProt ID: (Human) Q04864
Entrez Gene ID: (Human) 5966
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
negative regulation of cytokine production
regulation of transcription, DNA-templated
inflammatory response
I-kappaB kinase/NF-kappaB signaling
negative regulation of gene expression
negative regulation of interferon-beta production
response to cytokine
NIK/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
positive regulation of transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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