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Fabgennix

cGKI Polyclonal Antibody, FITC

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cGKI Polyclonal Antibody, FITC

Product Details

PKGA-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 609-659 on human protein kinase G alpha subunit.
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

PRKG1 is a cGMP-dependent serine/threonine kinase which has an important role in the relaxation of vascular smooth muscle and the inhibition of platelet aggregation. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cGK 1; cGK cGK cGKI; cGK cGK1; cGK1; cGKI; cGMP dependent protein kinase type 1; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I; OTTHUMP00000019618; protein kinase, cGMP-dependent, regulatory, type I, beta; protein kinase, cGMP-dependent, type I; RP11-346D6.1; unnamed protein product

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Gene Aliases: AAT8; AW125416; cGK; cGK 1; cGK1; CGKI; cGKI-alpha; cGKI-BETA; Gm19690; PKG; PKG1; Pkgi; PRKG1; PRKG1B; PRKGR1A; PRKGR1B

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UniProt ID: (Human) Q13976, (Mouse) P0C605

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Entrez Gene ID: (Human) 5592, (Mouse) 19091, (Rat) 54286

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Function(s)
nucleotide binding catalytic activity protein kinase activity protein serine/threonine kinase activity cGMP-dependent protein kinase activity calcium channel regulator activity protein binding ATP binding kinase activity transferase activity cGMP binding identical protein binding mitogen-activated protein kinase p38 binding protein serine kinase activity transferase activity, transferring phosphorus-containing groups protein homodimerization activity non-receptor serine/threonine protein kinase
Process(es)
neuron migration protein phosphorylation signal transduction positive regulation of cytosolic calcium ion concentration spermatid development heart development negative regulation of inositol phosphate biosynthetic process negative regulation of glutamate secretion negative regulation of smooth muscle cell migration dendrite development cGMP-mediated signaling cerebellum development actin cytoskeleton organization forebrain development vasodilation positive regulation of circadian rhythm regulation of GTPase activity regulation of vascular permeability negative regulation of smooth muscle contraction collateral sprouting relaxation of vascular smooth muscle cell growth involved in cardiac muscle cell development negative regulation of platelet aggregation bone growth negative regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration regulation of testosterone biosynthetic process metabolic process phosphorylation negative regulation of heart contraction positive regulation of vasodilation mitophagy in response to mitochondrial depolarization positive regulation of large conductance calcium-activated potassium channel activity brain development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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