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Invitrogen
cIAP1 Polyclonal Antibody
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FIGURE: 1 / 10
cIAP1 Antibody (PA5-47036) in ICC/IF
Immunofluorescence analysis of cIAP1 was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with cIAP1 Goat Polyclonal Antibody (Product # PA5-47036) at 5 µg/mL in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Rabbit anti-Goat IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 (Product # A-11078) at a dilution o... View More
Product Details
PA5-47036
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human cIAP-1/HIAP-2 His2-Ser618
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody does not cross-react with recombinant human cIAP-2 or XIAP.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptosis inhibitor 1; Baculoviral IAP repeat-containing protein 2; C-IAP1; Cellular inhibitor of apoptosis 1; hIAP-2; IAP homolog B; IAP-2; Inhibitor of apoptosis protein 2; NFR2-TRAF signalling complex protein; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; TNFR2-TRAF-signaling complex protein 2; unnamed protein product
Gene Aliases: API1; BIRC2; c-IAP1; cIAP1; Hiap-2; HIAP2; MIHB; RNF48
UniProt ID: (Human) Q13490
Entrez Gene ID: (Human) 329
transcription coactivator activity
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
ubiquitin binding
macromolecular complex binding
metal ion binding
chaperone binding
ubiquitin protein ligase activity
FBXO family protein binding
protein polyubiquitination
response to hypoxia
placenta development
apoptotic process
cell surface receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
positive regulation of protein ubiquitination
tumor necrosis factor-mediated signaling pathway
regulation of toll-like receptor signaling pathway
NIK/NF-kappaB signaling
regulation of RIG-I signaling pathway
regulation of cell proliferation
regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of innate immune response
response to ethanol
regulation of cell differentiation
positive regulation of transcription, DNA-templated
regulation of inflammatory response
response to cAMP
regulation of cell cycle
regulation of necroptotic process
negative regulation of necroptotic process
necroptotic process
regulation of nucleotide-binding oligomerization domain containing signaling pathway
cellular response to tumor necrosis factor
regulation of NIK/NF-kappaB signaling
negative regulation of ripoptosome assembly involved in necroptotic process
positive regulation of protein K63-linked ubiquitination
positive regulation of protein K48-linked ubiquitination
positive regulation of protein monoubiquitination
positive regulation of protein polyubiquitination
response to bleomycin
regulation of reactive oxygen species metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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