This antibody is predicted to react with human based on sequence homology.
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified.
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Protein Aliases: AIP 2; baculoviral IAP repeat-containing protein 3; H HIAP1; H MALT2; IAP homolog; inhibitor of apoptosis protein 1
Gene Aliases: Birc2; IAP1
Entrez Gene ID: (Rat) 78971