Immunogen sequence: QHAKWFPRCE YLIRIKGQEF IRQVQASYPH LLEQLLSTSD SPGDENAESS IIHFEPGEDH SEDAIMMNTP VINAAVEMGF SRSLVKQTVQ RKILATGENY RLVNDLVLDL LNAEDEIREE ERERATEE
Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 74%.
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified.
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Protein Aliases: AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2, IAP homolog C; API2; apoptosis inhibitor 1; Apoptosis inhibitor 2; baculoviral IAP repeat-containing 2; baculoviral IAP repeat-containing 3; Baculoviral IAP repeat-containing protein 3; C-IAP2; Cellular inhibitor of apoptosis 2; hIAP-1; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; mammalian IAP homolog C; mIAP-1; mIAP1; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1
Gene Aliases: AIP1; Api1; API2; AW107670; Birc2; BIRC3; c-IAP2; cIAP-1; cIAP-2; cIAP1; CIAP2; HAIP1; HIAP1; HIAP2; IAP1; IAP2; MALT2; MIAP1; MIAP2; MIHB; MIHC; RNF49