Fabgennix

cKit Polyclonal Antibody

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cKit Polyclonal Antibody

Product Details

CKIT-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Dog, Human, Non-human primate, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 130-180 on human Tyrosine-Kinase c-Kit protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-Kit; c-KIT gene1; CD117; ckit; Mast/stem cell growth factor receptor Kit; p145 c-kit; PBT; Piebald trait protein; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; soluble KIT variant 1; Tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein

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Gene Aliases: C-Kit; CD117; KIT; MGF; PBT; SCFR

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UniProt ID: (Dog) O97799, (Human) P10721, (Pig) Q2HWD6

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Entrez Gene ID: (Dog) 403811, (Human) 3815, (Pig) 396810

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Function(s)
transmembrane receptor protein tyrosine kinase activity ATP binding cytokine binding metal ion binding protease binding protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity stem cell factor receptor activity Ras guanyl-nucleotide exchange factor activity protein binding protein homodimerization activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity transmembrane signal receptor
Process(es)
activation of MAPK activity ovarian follicle development immature B cell differentiation dendritic cell cytokine production inflammatory response spermatogenesis regulation of cell shape peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway lamellipodium assembly T cell differentiation erythrocyte differentiation melanocyte differentiation actin cytoskeleton reorganization mast cell cytokine production embryonic hemopoiesis megakaryocyte development Fc receptor signaling pathway Kit signaling pathway erythropoietin-mediated signaling pathway mast cell degranulation pigmentation digestive tract development stem cell differentiation detection of mechanical stimulus involved in sensory perception of sound cell chemotaxis mast cell differentiation melanocyte migration melanocyte adhesion MAPK cascade myeloid progenitor cell differentiation lymphoid progenitor cell differentiation mast cell chemotaxis glycosphingolipid metabolic process signal transduction spermatid development positive regulation of cell proliferation germ cell migration visual learning male gonad development positive regulation of gene expression positive regulation of phospholipase C activity regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling stem cell population maintenance hemopoiesis positive regulation of cell migration positive regulation of pseudopodium assembly somatic stem cell population maintenance ectopic germ cell programmed cell death hematopoietic stem cell migration regulation of cell proliferation positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of tyrosine phosphorylation of Stat5 protein negative regulation of programmed cell death positive regulation of MAPK cascade positive regulation of GTPase activity positive regulation of phosphatidylinositol 3-kinase activity positive regulation of Notch signaling pathway positive regulation of JAK-STAT cascade protein autophosphorylation phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling regulation of developmental pigmentation somatic stem cell division positive regulation of long-term neuronal synaptic plasticity epithelial cell proliferation positive regulation of sequence-specific DNA binding transcription factor activity mast cell proliferation cellular response to thyroid hormone stimulus positive regulation of vascular smooth muscle cell differentiation
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