Search

  • 訂單查詢
  • 快速訂購

Fabgennix

cKit Polyclonal Antibody, FITC

View all (207) c-Kit (CD117) antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
cKit Polyclonal Antibody, FITC

Product Details

CKIT-121-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Dog, Human, Non-human primate, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 915-965 on human Tyrosine-Kinase c-Kit protein.
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: c-Kit; c-KIT gene1; c-Kit protooncogene; CD117; ckit; Mast/stem cell growth factor receptor Kit; p145 c-kit; PBT; Piebald trait protein; protein kinase; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; Tyrosine-protein kinase Kit; unnamed protein product; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein

View more View less

Gene Aliases: C-Kit; CD117; KIT; MASTC; MGF; PBT; SCFR

View more View less

UniProt ID: (Dog) O97799, (Human) P10721, (Pig) Q2HWD6

View more View less

Entrez Gene ID: (Dog) 403811, (Human) 3815, (Pig) 396810

View more View less

Function(s)
transmembrane receptor protein tyrosine kinase activity ATP binding cytokine binding metal ion binding nucleotide binding protease binding protein kinase activity protein tyrosine kinase activity stem cell factor receptor activity protein binding kinase activity transferase activity growth factor binding SH2 domain binding protein homodimerization activity transmembrane signal receptor
Process(es)
activation of MAPK activity ovarian follicle development immature B cell differentiation dendritic cell cytokine production inflammatory response spermatogenesis regulation of cell shape peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway lamellipodium assembly T cell differentiation erythrocyte differentiation melanocyte differentiation actin cytoskeleton reorganization mast cell cytokine production embryonic hemopoiesis megakaryocyte development Fc receptor signaling pathway Kit signaling pathway erythropoietin-mediated signaling pathway mast cell degranulation pigmentation digestive tract development stem cell differentiation detection of mechanical stimulus involved in sensory perception of sound cell chemotaxis mast cell differentiation melanocyte migration melanocyte adhesion hematopoietic progenitor cell differentiation myeloid progenitor cell differentiation lymphoid progenitor cell differentiation mast cell chemotaxis positive regulation of cytokine production involved in immune response positive regulation of dendritic cell cytokine production glycosphingolipid metabolic process chemotaxis signal transduction transmembrane receptor protein tyrosine kinase signaling pathway spermatid development cell proliferation positive regulation of cell proliferation germ cell migration gonad development visual learning male gonad development response to radiation positive regulation of gene expression programmed cell death cell migration stem cell population maintenance actin cytoskeleton organization hemopoiesis B cell differentiation positive regulation of cell migration positive regulation of pseudopodium assembly positive regulation of mast cell cytokine production somatic stem cell population maintenance ectopic germ cell programmed cell death intracellular signal transduction hematopoietic stem cell migration regulation of cell proliferation positive regulation of tyrosine phosphorylation of STAT protein negative regulation of programmed cell death positive regulation of MAPK cascade tongue development leukocyte activation positive regulation of Notch signaling pathway positive regulation of JAK-STAT cascade response to cadmium ion protein autophosphorylation developmental pigmentation positive regulation of long-term neuronal synaptic plasticity epithelial cell proliferation regulation of developmental process positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of developmental process positive regulation of protein kinase B signaling mast cell proliferation positive regulation of mast cell proliferation positive regulation of pyloric antrum smooth muscle contraction regulation of bile acid metabolic process positive regulation of colon smooth muscle contraction positive regulation of small intestine smooth muscle contraction positive regulation of vascular smooth muscle cell differentiation negative regulation of reproductive process
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support