Immunogen sequence: PDEDEILEKD EALEDEDNKK DDGISFSNQT GPAWAGSERD YTYEELLNRV FNIMREKNPD MVAGEKRKFV MKPPQVVRVG TKKTSFVNFT DICKLLHRQP KHLLAFLLAE LGTSGSIDGN NQLVIKGRFQ QKQIENVLRR YIKEYVTCHT CRSPDTILQK DTRLYFLQCE TCHSRCSVAS IKTGFQAVTG KRAQLRAKAN; Positive Samples: HeLa, SKOV3, HepG2, Mouse heart, Mouse spinal cord
Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: eIF-2-beta; EIF2BA; Eukaryotic translation initiation factor 2 subunit 2; Eukaryotic translation initiation factor 2 subunit beta; eukaryotic translation initiation factor 2, subunit 2 (beta, 38kDa); eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; protein phosphatase 1, regulatory subunit 67
Gene Aliases: 2810026E11Rik; 38kDa; AA408636; AA571381; AA986487; AW822225; D2Ertd303e; eIF-2-beta; EIF2; EIF2B; EIF2beta; EIF2S2; PPP1R67
Molecular Function: translation initiation factor