PA5-27585 targets EIF3F in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-27585 immunogen is recombinant fragment corresponding to a region within amino acids 55 and 328 of Human EIF3F.
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Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
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Protein Aliases: 47kD); 47kDa; Deubiquitinating enzyme eIF3f; eIF-3-epsilon; eIF3 p47; eIF3-epsilon; eIF3-p47; EIF3F; EIF3S5; eukaryotic translation initiation factor 3; Eukaryotic translation initiation factor 3 subunit 5; Eukaryotic translation initiation factor 3 subunit F; eukaryotic translation initiation factor 3, subunit 5 (epsilon, 47kD); eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa; eukaryotic translation initiation factor 3, subunit F; subunit 5 (epsilon; subunit 5 epsilon
Gene Aliases: eIF3-p47; EIF3F; EIF3S5
UniProt ID: (Human) O00303
Entrez Gene ID: (Human) 8665