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Invitrogen
eIF4A1 Polyclonal Antibody
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Product Details
PA5-115167
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human EIF4A1(Accession P60842), corresponding to amino acid residues V22-V72.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total EIF4A1.
Target Information
eIF4A2 is a 407 amino acid ATP-dependent RNA helicase belonging to the DEAD box helicase family. It contains one helicase ATP-binding domain and a helicase C-terminal domain. eIF4A2, a subunit of the eIF4F complex, acts as a protein-synthesis initiation factor and thus plays an important role in the binding of mRNA to the 43S pre-initiation complex of ribosomes. Human eIF4A2 interacts with the NS5B protein of Hepatitis C virus (HCV) and facilitates the genomic RNA synthesis of NS5B protein by unwinding the secondary structure of the HCV genome. It is ubiquitously expressed in most of normal tissues, but in variable amounts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent RNA helicase eIF4A-1; eIF-4A-I; eIF4A-I; Eukaryotic initiation factor 4A-I; eukaryotic initiation factor 4AI; eukaryotic translation initiation factor 4A, isoform 1; initiation factor eIF-4A long form
Gene Aliases: BM-010; DDX2A; EIF-4A; eIF-4A-I; Eif4; EIF4A; eIF4A-I; EIF4A1
UniProt ID: (Human) P60842, (Mouse) P60843
Entrez Gene ID: (Human) 1973, (Mouse) 13681, (Rat) 287436
RNA cap binding
double-stranded RNA binding
mRNA binding
translation initiation factor activity
ATP-dependent RNA helicase activity
helicase activity
protein binding
ATP binding
translation factor activity, RNA binding
poly(A) RNA binding
nucleotide binding
nucleic acid binding
RNA binding
hydrolase activity
molecular_function
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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