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Invitrogen
eIF4A3 Polyclonal Antibody
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Product Details
PA5-54532
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human eIF4A3. Recombinant protein control fragment (Product #RP-93301).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MATTATMATS GSARKRLLKE EDMTKVEFET SEEVDVTPTF DTMGLREDLL RGIYAYGFEK PSAIQQRAIK QIIK
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 99%.
Target Information
eIF4A3 is a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. eIF4A3 is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DDX48; DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; DEAD box protein 48; eIF-4A-III; Eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-like NUK-34; Eukaryotic translation initiation factor 4A isoform 3; KIAA0111; NMP 265; Nuclear matrix protein 265; unnamed protein product
Gene Aliases: DDX48; eIF-4A-III; eIF4A-III; EIF4A3; eIF4AIII; Fal1; KIAA0111; MUK34; NMP265; NUK34; RCPS
UniProt ID: (Human) P38919
Entrez Gene ID: (Human) 9775
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
mRNA splicing, via spliceosome
rRNA processing
mRNA processing
mRNA export from nucleus
regulation of translation
associative learning
RNA splicing
negative regulation of gene expression
negative regulation of translation
exploration behavior
positive regulation of translation
embryonic cranial skeleton morphogenesis
mRNA transport
cellular response to selenite ion
negative regulation of excitatory postsynaptic potential
regulation of translation at postsynapse, modulating synaptic transmission
negative regulation of selenocysteine incorporation
cellular response to brain-derived neurotrophic factor stimulus
regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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