This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
This antibody detects endogenous protein at a molecular weight of 27 kDa.
Purity is >95% by SDS-PAGE.
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B(2)GCN homolog; B4 integrin interactor; CAB; eIF-6; EIF3A; EIF6; eukaryotic translation initiation factor 3A; Eukaryotic translation initiation factor 6; ITGB4BP; OK/SW-cl.27; p27 beta-4 integrin-binding protein; p27(BBP)
Gene Aliases: b(2)gcn; CAB; eIF-6; EIF3A; EIF6; ITGB4BP; OK/SW-cl.27; p27(BBP); p27BBP
UniProt ID: (Human) P56537
Entrez Gene ID: (Human) 3692