Immunogen sequence: MAVRASFENN CEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSDTIPVVH ASIAGCRIIG RMCVGNRHGL LVPNNTTDQE LQHIRNSLPD TVQIRRVEER LSALGNVTTC NDYVALVHPD LDRETEEILA DVLKVEVFRQ TVADQVLVGS YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP LVAGTVNRGS EVIAAGMVVN DWCAFCGLDT TSTELSVVES VFKLNEAQPS TIATSMRDSL IDSLT; Positive Samples: U-251MG, HeLa, 293T, HepG2, K-562; Cellular Location: Cytoplasm, Nucleus, nucleolus
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding two different isoforms have been found for this gene.
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Protein Aliases: B(2)GCN homolog; B4 integrin interactor; CAB; eIF-6; EIF6; eukaryotic translation initiation factor 3A; Eukaryotic translation initiation factor 6; p27 beta-4 integrin-binding protein; p27(BBP)
Gene Aliases: b(2)gcn; CAB; eIF-6; EIF3A; EIF6; ITGB4BP; OK/SW-cl.27; p27(BBP); p27BBP
UniProt ID: (Human) P56537
Entrez Gene ID: (Human) 3692