This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
PA3-840 detects mitochondrial dicarboxylate carrier protein(mDIC) in human and mouse cells.
PA3-840 has been successfully used in Western blotting and ICC/IF procedures. By Western blot it detects a 28 kDa protein representing mDIC.
The PA3-840 immunogen is a synthetic peptide corresponding to the C-terminal residues L(276) R K H F G I K V P T T(287) of mDIC.
The mitochondrial dicarboxylate carrier protein (mDIC) belongs to superfamily of mitochondrial transporters. It has been demonstrated that the expression of mDIC leads to hyperpolarization of the mitochondria, as well as succinate uptake by the mitochondria. It is highly expressed in adipose tissue, where its expression is downregulated by insulin and upregulated by free fatty acids. mDIC is also thought to play a role in glyceroneogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: dicarboxylate ion carrier; Mitochondrial dicarboxylate carrier; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 10; solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10; Solute carrier family 25 member 10
Gene Aliases: DIC; SLC25A10