PA1-4516 detects Metabotropic Glutamate Receptor 1 in human, rat, and mouse samples.
PA1-4516 has been successfully used in Western blot and Immunohistochemistry procedures.
PA1-4516 immunogen is a synthetic peptide corresponding to residues 1159-1171 of the human GluR1 protein.
Maintain at 4°C for 3 months or at -20°C for longer periods. Avoid freeze/thaw cycles.
Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member A; glutamate receptor; glutamate receptor, metabotropic 1; GRM1A; Metabotropic glutamate receptor 1; mGluR1; mGluR1a; protein phosphatase 1, regulatory subunit 85
Gene Aliases: 4930455H15Rik; ENSMUSG00000075319; Gm10828; GPRC1A; GRM1; MGLU1; MGLUR1; nmf373; PPP1R85; rcw; SCAR13; wobl