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Invitrogen
mGluR1 Polyclonal Antibody
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FIGURE: 1 / 3
mGluR1 Antibody (PA1-46151) in IHC (F)
Immunohistochemical analysis of GluR1 in rat brain (cingulate cortex). Frozen samples were incubated in GluR1 polyclonal antibody (Product # PA1-46151) using a dilution of 1:100-1:500. GluR1 detection was done using anti-rabbit Cy3 conjugated antibodies (red color). DAPI was used to counterstain cell nuclei (blue color).
Product Details
PA1-46151
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Rat
Published species
Guinea pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide comprising residues 1159-1171 of the human mGluR1 protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: human brain lysate, rat dorsal root ganglion, and rat brain (cingulate cortex), antigen standard for GRIN1 (transient overexpression lysate).
Immunogen sequence: SSVPSSPVSE SVL
Target Information
Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member A; glutamate receptor; glutamate receptor, metabotropic 1; GRM1A; Metabotropic glutamate receptor 1; mGluR1; mGluR1a; protein phosphatase 1, regulatory subunit 85
Gene Aliases: 4930455H15Rik; ENSMUSG00000075319; Gm10828; GPRC1A; GRM1; MGLU1; MGLUR1; nmf373; PPP1R85; rcw; SCA44; SCAR13; wobl
UniProt ID: (Human) Q13255, (Mouse) P97772, (Rat) P23385
Entrez Gene ID: (Human) 2911, (Chicken) 421614, (Mouse) 14816, (Rat) 24414
adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
G-protein coupled receptor activity
protein binding
glutamate receptor activity
G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
PLC activating G-protein coupled glutamate receptor activity
signal transducer activity
estrogen receptor binding
identical protein binding
G-protein coupled receptor
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
locomotory behavior
sensory perception of pain
regulation of membrane potential
positive regulation of MAPK cascade
regulation of sensory perception of pain
regulation of synaptic transmission, glutamatergic
regulation of postsynaptic membrane potential
cellular response to electrical stimulus
L-glutamate import across plasma membrane
synaptic signaling via neuropeptide
regulation of postsynaptic cytosolic calcium ion concentration
activation of MAPKK activity
activation of MAPK activity
protein kinase C-activating G-protein coupled receptor signaling pathway
calcium-mediated signaling
dimeric G-protein coupled receptor signaling pathway
regulation of MAPK cascade
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
regulation of glutamate secretion
membrane depolarization
synaptic transmission, GABAergic
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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