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Product Details
PA5-99485
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GRM3(Accession Q14832), corresponding to amino acid residues S847-L879.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2818418
Product Specific Information
Antibody detects endogenous levels of total GluR2/3.
Target Information
The mGluR proteins (metabotropic Glutamate Receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic Glutamate Receptors). The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G-protein that inhibits adenylate cyclase activity. mGluR-3, which may interact with GRASP, acts as a receptor for glutamate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member C; glutamate receptor; glutamate receptor homolog; glutamate receptor, metabotropic 2; glutamate receptor, metabotropic 3; M mGlu3; Metabotropic glutamate receptor 2; Metabotropic glutamate receptor 3; mGluR2; mGluR3
Gene Aliases: 0710001G23Rik; 4930441L02Rik; GLUR2; GLUR3; GPRC1B; GPRC1C; GRM2; GRM3; mGlu2; mGlu3; MGLUR2; MGLUR3; mGluR7
UniProt ID: (Human) Q14416, (Human) Q14832, (Mouse) Q14BI2, (Rat) P31421, (Mouse) Q9QYS2, (Rat) P31422
Entrez Gene ID: (Human) 2912, (Human) 2913, (Mouse) 108068, (Rat) 24415, (Mouse) 108069, (Rat) 24416
negative regulation of adenylate cyclase activity
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
glutamate secretion
regulation of synaptic transmission, glutamatergic
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
regulation of neurotransmitter secretion
sensory perception of pain
synaptic transmission, glutamatergic
modulation of synaptic transmission
regulation of sensory perception of pain
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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