Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.
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Protein Aliases: glutamate receptor; glutamate receptor, metabotropic 3; M mGlu3; Metabotropic glutamate receptor 3; mGluR3
Gene Aliases: GLUR3; GPRC1C; GRM3; mGlu3; MGLUR3
UniProt ID: (Human) Q14832
Entrez Gene ID: (Human) 2913