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Invitrogen
mGluR8 Polyclonal Antibody
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Product Details
PA5-11697
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 852-882 amino acids from the C-terminal region of human Metabotropic Glutamate Receptor 8
Conjugate
Form
Liquid
Concentration
1.7 mg/mL
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with rat based on sequence homology.
Target Information
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ41058; G protein coupled receptor, family C, group 1, member H; G protein-coupled receptor, family C, group 1, member H; glutamate receptor; glutamate receptor, metabotropic 8; M mGlu8; Metabotropic glutamate receptor 8; MGC126724; mGluR8
Gene Aliases: A230002O04; GLUR8; GPRC1H; GRM8; mGlu8; MGLUR8
UniProt ID: (Human) O00222, (Mouse) P47743
Entrez Gene ID: (Human) 2918, (Mouse) 14823
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
visual perception
sensory perception of smell
negative regulation of cAMP biosynthetic process
regulation of synaptic transmission, glutamatergic
signal transduction
G-protein coupled receptor signaling pathway
chemical synaptic transmission
synaptic transmission, glutamatergic
regulation of neurotransmitter secretion
response to stimulus
detection of mechanical stimulus involved in sensory perception of pain
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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