This Antibody was verified by IP Mass Spectrometry to ensure that the antibody binds to the antigen stated. View Details
3-8% Tris-Acetate Gel is recommended for Western blot.
PA1-518 detects a predominant band at ~290kD corresponding to mTOR. Other lower MW nonspecific bands of unknown identity were also detected at ~65kD and ~35kD in some cell lysates.
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that plays a key role in cell growth, cell proliferation, and protein synthesis. mTOR mediates phosphoinositide 3-kinase and Akt/PKB signaling, resulting in phosphorylation of 4EBP1, and initiation of mRNA translation. A second pathway involves regulation of ribosomal S6 kinase, which affects ribosome biogenesis and translation elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: angiopoietin-like factor CDT6; EC 126.96.36.199; FK506 binding protein 12-rapamycin associated protein; FK506 binding protein 12-rapamycin associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-Rapamycin Associated Protein; FKBP-rapamycin associated protein (FRAP); FKBP-rapamycin-associated protein FRAP; FKBP12-rapamycin complex-associated protein; FKBP12-rapamycin complex-associated protein 1; FRAP1; FRAP2; m-TOR; Mammalian Target Of Rapamycin; Mechanistic Target Of Rapamycin; mechanistic target of rapamycin (serine/threonine kinase); MTOR; mTORC1; RAFT1; Rapamycin and FKBP12 target 1; rapamycin and FKBP12 target-1 protein; rapamycin associated protein FRAP2; Rapamycin Target Protein; Rapamycin target protein 1; RAPT1; Serine/Threonine-Protein Kinase MTOR
Gene Aliases: 2610315D21Rik; AI327068; flat; FRAP; FRAP1; FRAP2; MTOR; RAFT1; RAPT1; SKS