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Invitrogen
nNOS Polyclonal Antibody
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Product Details
PA1-4121
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues P(19) R K G P P L P N G D T E C(31) of nNOS.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-4121 detects neuronal Nitric Oxide Synthase in human samples.
PA1-4121 has been successfully used in Western blot procedures.
The PA1-4121 immunogen is a synthetic peptide corresponding to residues P(19) R K G P P L P N G D T E C(31) of nNOS.
Target Information
NOS activity requires homodimerization as well as three cosubstrates (L-arginine, NADPH and O2) and five cofactors or prosthetic groups (FAD, FMN, calmodulin, tetrahydrobiopterin and heme). Several distinct NOS isoforms have been described and been shown to represent the products of three distinct genes. These include two constitutive Ca2+/CaM-dependent forms of NOS, including NOS1 (also designated ncNOS) whose activity was first identified in neurons, and NOS3 (also designated ecNOS), first identified in endothelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bNOS; bNOS1; Brain NOS; Constitutive NOS; N-NOS; NC-NOS; Neuronal NOS; Nitric oxide synthase 1; nitric oxide synthase 1 (neuronal); Nitric oxide synthase, brain; NOS Type 1; NOS type I; Peptidyl-cysteine S-nitrosylase NOS1; Phospho-bNOS; Phospho-Brain NOS; unnamed protein product
Gene Aliases: bNOS; IHPS1; N-NOS; NC-NOS; nNOS; NOS; NOS1
UniProt ID: (Human) P29475
Entrez Gene ID: (Human) 4842
nitric-oxide synthase activity
calcium channel regulator activity
protein binding
calmodulin binding
FMN binding
oxidoreductase activity
sodium channel regulator activity
heme binding
tetrahydrobiopterin binding
arginine binding
peptidyl-cysteine S-nitrosylase activity
ion channel binding
cadmium ion binding
metal ion binding
calcium-dependent protein binding
flavin adenine dinucleotide binding
NADP binding
scaffold protein binding
response to hypoxia
regulation of sodium ion transport
arginine catabolic process
nitric oxide biosynthetic process
potassium ion transport
calcium ion transport
striated muscle contraction
cell communication
nitric oxide mediated signal transduction
myoblast fusion
blood circulation
response to heat
response to hormone
negative regulation of calcium ion transport into cytosol
regulation of cardiac muscle contraction by calcium ion signaling
regulation of metal ion transport
signaling
response to lipopolysaccharide
multicellular organismal response to stress
xenobiotic catabolic process
vasodilation
negative regulation of potassium ion transport
negative regulation of ion transport
positive regulation of neuron apoptotic process
cell redox homeostasis
negative regulation of blood pressure
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of neurogenesis
negative regulation of serotonin uptake
establishment of localization in cell
negative regulation of calcium ion transport
regulation of cardiac muscle contraction
regulation of postsynaptic membrane potential
regulation of biological quality
cellular response to growth factor stimulus
positive regulation of the force of heart contraction
synaptic signaling by nitric oxide
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of sodium ion transmembrane transport
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
regulation of blood circulation
positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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