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p107 Polyclonal Antibody
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Product Details
BS-4184R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human p107/RBL1, amino acids 751-850.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
RB-like 1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and RB-like 1 can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that RB-like 1 may also be a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 107 kDa retinoblastoma-associated protein; MGC40006; p107; pRb1; retinoblastoma-like 1; Retinoblastoma-like protein 1; unnamed protein product
Gene Aliases: AW547426; CP107; p107; PRB1; RBL1
UniProt ID: (Human) P28749, (Mouse) Q64701, (Rat) D3ZS28
Entrez Gene ID: (Human) 5933, (Mouse) 19650, (Rat) 680111
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
regulation of transcription from RNA polymerase II promoter
regulation of gene expression
negative regulation of macromolecule biosynthetic process
negative regulation of gene expression
cell differentiation
regulation of lipid kinase activity
regulation of cell cycle
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of cellular senescence
transcription, DNA-templated
regulation of transcription, DNA-templated
cell cycle
chromatin modification
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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