Immunogen sequence: DPDTKLIGNM ALLPIRSQFK GPAPRETKDT DIVDEAIYYF KANVFFKNYE IKNEADRTLI YITLYISECL KKLQKCNSKS QGEKEMYTLG ITNFPIPGEP GFPLNAIYAK PANKQEDEVM RAYLQQLRQE TGLRLCEKVF DPQNDKPSK
The maf oncogene was identified by structural analysis of the AS42 avian transforming retrovirus genome. The Maf family is divided into two subclasses, large Mafs (vMaf, cMaf, MafB and Nrl) and small Mafs (MafF, MafK, and MafG). Both subclasses contain leucinezipper motifs, which allow homodimerization as well as heterodimerization with a variety of other bZip transcription factors. Large Mafs also contain an acidic transactivation domain absent in the small Maf proteins. Although they do not possess inherent transactivation activity, small Maf proteins can act as positive regulators of transcription by targeting transcriptionally active dimerization partners to specific DNA regulatory elements. Conversely, small Mafs can act also as negative regulators of transcription by recruiting transcriptional repressors or by forming homodimers that can replace active dimers. Human MafF was isolated in a yeast one-hybrid system from a human myometrium cDNA library. Human MAFF encodes a 164 amino acids protein. Like other small MAFF proteins, it contains an extended leucine zipper structure and lacks an N-terminal transactivating domain. The three small Maf proteins have been implicated in a number of physiological processes, including development, differentiation, haematopoiesis and stress response. Interestingly, these three proteins regulate the stress response via different mechanisms.
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Protein Aliases: actin related protein 2/3 complex subunit 3, 21kDa; actin related protein 2/3 complex, subunit 3, 21kDa; Actin-related protein 2/3 complex subunit 3; ARC21; Arp2/3 complex 21 kDa subunit; Arp2/3 complex subunit p21-Arc; ARP2/3 protein complex subunit p21; p21-ARC
Gene Aliases: 1110006A04Rik; 21kDa; AA408672; AI788639; ARC21; ARPC3; p21-Ar; p21-Arc; p21Arc