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Proteintech
p21 Polyclonal Antibody
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Product Details
28248-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Cdkn1a Fusion Protein Ag28394
Conjugate
Form
Liquid
Concentration
467 µg/mL
Amount
70.05 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases:
Activating Fragment 1; CDK-interacting protein 1; CDNK1A; Cip1); Cyclin-dependent kinase inhibitor 1; Cyclin-dependent kinase inhibitor 1A (p21; cyclin-dependent kinase inhibitor 1A (P21); cyclin-dependent kinase inhibitor 1A (p21, Cip1); cyclin-dependent kinase inhibitor 1A variant 1; cyclin-dependent kinase inhibitor 1A variant 2; Melanoma differentiation-associated protein; OTTHUMP00000016298; p21; p21
Gene Aliases: CAP20; CDKI; Cdkn1; Cdkn1a; CIP1; mda6; P21; p21Cip1; p21WAF; SDI1; UV96; Waf1
UniProt ID: (Mouse) P39689
Entrez Gene ID: (Mouse) 12575, (Rat) 114851
regulation of cyclin-dependent protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
protein phosphorylation
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cell cycle
cell cycle arrest
regulation of mitotic cell cycle
negative regulation of cell proliferation
response to UV
negative regulation of gene expression
negative regulation of cell growth
positive regulation of B cell proliferation
cellular response to extracellular stimulus
regulation of protein import into nucleus, translocation
negative regulation of phosphorylation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of apoptotic process
positive regulation of programmed cell death
negative regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of fibroblast proliferation
regulation of cell cycle
cellular response to ionizing radiation
cellular response to UV-B
mitotic cell cycle arrest
signal transduction by p53 class mediator
cellular senescence
negative regulation of G1/S transition of mitotic cell cycle
regulation of DNA biosynthetic process
positive regulation of reactive oxygen species metabolic process
Ras protein signal transduction
response to toxic substance
response to organic substance
response to X-ray
response to organonitrogen compound
response to organic cyclic compound
organ regeneration
cellular response to heat
response to drug
response to arsenic-containing substance
response to glucocorticoid
response to corticosterone
response to hyperoxia
intestinal epithelial cell maturation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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