Product References
Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts.
Journal of biomedical science
Jung YH,Chae CW,Choi GE,Shin HC,Lim JR,Chang HS,Park J,Cho JH,Park MR,Lee HJ,Han HJ
MA5-14949 was used in Western Blot to investigate mechanisms of mitochondrial dysfunction in androgenetic alopecia.
Mon Mar 07 00:00:00 EST 2022
Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts.
Journal of biomedical science
Jung YH,Chae CW,Choi GE,Shin HC,Lim JR,Chang HS,Park J,Cho JH,Park MR,Lee HJ,Han HJ
MA5-14949 was used in Western Blot to investigate mechanisms of mitochondrial dysfunction in androgenetic alopecia.
Mon Mar 07 00:00:00 EST 2022
Palbociclib-mediated cell cycle arrest can occur in the absence of the CDK inhibitors p21 and p27.
Open biology
Pennycook BR,Barr AR
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Mon Nov 01 00:00:00 EDT 2021
Palbociclib-mediated cell cycle arrest can occur in the absence of the CDK inhibitors p21 and p27.
Open biology
Pennycook BR,Barr AR
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Mon Nov 01 00:00:00 EDT 2021
Baricitinib, a JAK-STAT Inhibitor, Reduces the Cellular Toxicity of the Farnesyltransferase Inhibitor Lonafarnib in Progeria Cells.
International journal of molecular sciences
Arnold R,Vehns E,Randl H,Djabali K
MA5-14949 was used in Immunocytochemistry to suggest that combining lonafarnib with baricitinib might provide an opportunity to reduce FTI cellular toxicity and ameliorate HGPS symptoms further than lonafarnib alone.
Mon Jul 12 00:00:00 EDT 2021
The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence.
Aging
Bloniarz D,Adamczyk-Grochala J,Lewinska A,Wnuk M
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Thu Jun 17 00:00:00 EDT 2021
Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes.
Aging
Schwartz RE,Shokhirev MN,Andrade LR,Gutkind JS,Iglesias-Bartolome R,Shadel GS
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Fri Feb 12 00:00:00 EST 2021
Decreased p53 is associated with a decline in asymmetric stem cell self-renewal in aged human epidermis.
Aging cell
Charruyer A,Weisenberger T,Li H,Khalifa A,Schroeder AW,Belzer A,Ghadially R
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Mon Feb 01 00:00:00 EST 2021
Decreased p53 is associated with a decline in asymmetric stem cell self-renewal in aged human epidermis.
Aging cell
Charruyer A,Weisenberger T,Li H,Khalifa A,Schroeder AW,Belzer A,Ghadially R
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Mon Feb 01 00:00:00 EST 2021
Interleukin-6 neutralization ameliorates symptoms in prematurely aged mice.
Aging cell
Squarzoni S,Schena E,Sabatelli P,Mattioli E,Capanni C,Cenni V,D'Apice MR,Andrenacci D,Sarli G,Pellegrino V,Festa A,Baruffaldi F,Storci G,Bonafè M,Barboni C,Sanapo M,Zaghini A,Lattanzi G
MA5-14949 was used in Western Blot to show that tocilizumab counteracts aberrant differentiation of adipocytes and osteoblasts, improves adipose tissue dystrophy, aorta histological lesions, and skeletal deterioration, and positively impacts the overall condition of progeroid mice, while reducing progerin accumulation and its deleterious effects in mouse and human progeria cells.
Fri Jan 01 00:00:00 EST 2021
Interleukin-6 neutralization ameliorates symptoms in prematurely aged mice.
Aging cell
Squarzoni S,Schena E,Sabatelli P,Mattioli E,Capanni C,Cenni V,D'Apice MR,Andrenacci D,Sarli G,Pellegrino V,Festa A,Baruffaldi F,Storci G,Bonafè M,Barboni C,Sanapo M,Zaghini A,Lattanzi G
MA5-14949 was used in Western Blot to show that tocilizumab counteracts aberrant differentiation of adipocytes and osteoblasts, improves adipose tissue dystrophy, aorta histological lesions, and skeletal deterioration, and positively impacts the overall condition of progeroid mice, while reducing progerin accumulation and its deleterious effects in mouse and human progeria cells.
Fri Jan 01 00:00:00 EST 2021
Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models.
International journal of molecular sciences
Krenacs T,Meggyeshazi N,Forika G,Kiss E,Hamar P,Szekely T,Vancsik T
MA5-14949 was used in Immunohistochemistry-immunofluorescence to review the mEHT-related damage mechanisms published in tumor models.
Sat Aug 29 00:00:00 EDT 2020
Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models.
International journal of molecular sciences
Krenacs T,Meggyeshazi N,Forika G,Kiss E,Hamar P,Szekely T,Vancsik T
MA5-14949 was used in Immunohistochemistry-immunofluorescence to review the mEHT-related damage mechanisms published in tumor models.
Sat Aug 29 00:00:00 EDT 2020
Sodium butyrate inhibits high cholesterol-induced neuronal amyloidogenesis by modulating NRF2 stabilization-mediated ROS levels: involvement of NOX2 and SOD1.
Cell death & disease
Kim SY,Chae CW,Lee HJ,Jung YH,Choi GE,Kim JS,Lim JR,Lee JE,Cho JH,Park H,Park C,Han HJ
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Thu Jun 18 00:00:00 EDT 2020
Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization.
Cells
Cenni V,Squarzoni S,Loi M,Mattioli E,Lattanzi G,Capanni C
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Sat Jun 06 00:00:00 EDT 2020
Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization.
Cells
Cenni V,Squarzoni S,Loi M,Mattioli E,Lattanzi G,Capanni C
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Sat Jun 06 00:00:00 EDT 2020
AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts.
Redox biology
Lewinska A,Adamczyk-Grochala J,Bloniarz D,Olszowka J,Kulpa-Greszta M,Litwinienko G,Tomaszewska A,Wnuk M,Pazik R
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunofluorescence
Wed Jan 01 00:00:00 EST 2020
AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts.
Redox biology
Lewinska A,Adamczyk-Grochala J,Bloniarz D,Olszowka J,Kulpa-Greszta M,Litwinienko G,Tomaszewska A,Wnuk M,Pazik R
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunofluorescence
Wed Jan 01 00:00:00 EST 2020
AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts.
Redox biology
Lewinska A,Adamczyk-Grochala J,Bloniarz D,Olszowka J,Kulpa-Greszta M,Litwinienko G,Tomaszewska A,Wnuk M,Pazik R
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunofluorescence
Wed Jan 01 00:00:00 EST 2020
Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells.
Cells
Liu C,Arnold R,Henriques G,Djabali K
MA5-14949 was used in Western Blotting to report that the inhibition of the JAK-STAT pathway with baricitinib, a Food and Drug Administration-approved JAK1/2 inhibitor, restored cellular homeostasis, delayed senescence and decreased proinflammatory markers in HGPS cells.
Fri Oct 18 00:00:00 EDT 2019
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS.
Aging cell
Mattioli E,Andrenacci D,Garofalo C,Prencipe S,Scotlandi K,Remondini D,Gentilini D,Di Blasio AM,Valente S,Scarano E,Cicchilitti L,Piaggio G,Mai A,Lattanzi G
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Mon Oct 01 00:00:00 EDT 2018
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS.
Aging cell
Mattioli E,Andrenacci D,Garofalo C,Prencipe S,Scotlandi K,Remondini D,Gentilini D,Di Blasio AM,Valente S,Scarano E,Cicchilitti L,Piaggio G,Mai A,Lattanzi G
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Mon Oct 01 00:00:00 EDT 2018
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS.
Aging cell
Mattioli E,Andrenacci D,Garofalo C,Prencipe S,Scotlandi K,Remondini D,Gentilini D,Di Blasio AM,Valente S,Scarano E,Cicchilitti L,Piaggio G,Mai A,Lattanzi G
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Mon Oct 01 00:00:00 EDT 2018
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS.
Aging cell
Mattioli E,Andrenacci D,Garofalo C,Prencipe S,Scotlandi K,Remondini D,Gentilini D,Di Blasio AM,Valente S,Scarano E,Cicchilitti L,Piaggio G,Mai A,Lattanzi G
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Mon Oct 01 00:00:00 EDT 2018
Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression.
Redox biology
Lewinska A,Adamczyk-Grochala J,Kwasniewicz E,Deregowska A,Semik E,Zabek T,Wnuk M
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Western Blot
Sun Apr 01 00:00:00 EDT 2018
Detection of mesenchymal stem cells senescence by prelamin A accumulation at the nuclear level.
SpringerPlus
Bellotti C,Capanni C,Lattanzi G,Donati D,Lucarelli E,Duchi S
MA514949 was used in immunocytochemistry to correlate lamin A maturation and cellular senescence
Wed Sep 14 00:00:00 EDT 2016
Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide.
Cell cycle (Georgetown, Tex.)
Huna A,Salmina K,Erenpreisa J,Vazquez-Martin A,Krigerts J,Inashkina I,Gerashchenko BI,Townsend PA,Cragg MS,Jackson TR
MA5-14949 was used in western blot to elucidate the mechanism of p53-dependent upregulation of OCT4A and p21Cip1.
Wed Aug 03 00:00:00 EDT 2016
Disentangling the aneuploidy and senescence paradoxes: a study of triploid breast cancers non-responsive to neoadjuvant therapy.
Histochemistry and cell biology
Gerashchenko BI,Salmina K,Eglitis J,Huna A,Grjunberga V,Erenpreisa J
MA5-14949 was used in immunohistochemistry to analyze triploid breast cancers non-responsive to neoadjuvant therapy by study of aneuploidy and senescence paradoxes
Fri Apr 01 00:00:00 EDT 2016
Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Verreault M,Schmitt C,Goldwirt L,Pelton K,Haidar S,Levasseur C,Guehennec J,Knoff D,Labussière M,Marie Y,Ligon AH,Mokhtari K,Hoang-Xuan K,Sanson M,Alexander BM,Wen PY,Delattre JY,Ligon KL,Idbaih A
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Tue Mar 01 00:00:00 EST 2016
Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Verreault M,Schmitt C,Goldwirt L,Pelton K,Haidar S,Levasseur C,Guehennec J,Knoff D,Labussière M,Marie Y,Ligon AH,Mokhtari K,Hoang-Xuan K,Sanson M,Alexander BM,Wen PY,Delattre JY,Ligon KL,Idbaih A
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Tue Mar 01 00:00:00 EST 2016
Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line.
Molecular cancer
Waby JS,Chirakkal H,Yu C,Griffiths GJ,Benson RS,Bingle CD,Corfe BM
Published figure using p21 monoclonal antibody (Product # MA5-14949) in Immunocytochemistry
Fri Oct 15 00:00:00 EDT 2010